Nsun6 MGI Mouse Gene Detail - MGI:1921705 - NOL1/NOP2/Sun domain family member 6

Nsun6 Gene Detail

Symbol

Nsun6
Name

NOL1/NOP2/Sun domain family member 6
Synonyms

4933403D21Rik, 4933414E04Rik, NOPD1

Feature Type

protein coding gene
IDs

MGI:1921705
NCBI Gene: 74455
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:14999942-15059880 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 10.94 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

1486 from dbSNP Build 142
Strain Annotations

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921705	protein coding gene	Chr2:14995255-15059880 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0023196	protein coding gene	Chr2:11591894-11644282 (-)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0024312	protein coding gene	Chr2:11822180-11881855 (-)
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

NSUN6, NOP2/Sun RNA methyltransferase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NSUN6, NOP2/Sun RNA methyltransferase 6
Synonyms

4933414E04Rik, ARL5B-AS1, MRT82, NOPD1
Links

HGNC:23529

NCBI Gene ID: 221078

neXtProt AC: NX_Q8TEA1

UniProt: Q8TEA1
Chr Location

10p12.31; chr10:18545561-18659327 (-) GRCh38

MGI Vertebrate Homology

Nsun6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NSUN6
Gene Tree

Nsun6

Diseases

1 with human NSUN6 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 82 IDs autosomal recessive intellectual developmental disorder 82 DOID:0060947 OMIM:620779

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

All Mutations and Alleles

12
Endonuclease-mediated

6
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

Mice homozygous for a knock-out allele exhibit normal embryonic development.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

40
cDNA Data

20
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nsun6

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All Sequences

50
RefSeq

18
UniProt

3
CCDS

CCDS15703.1, CCDS50506.1, CCDS50507.1

Ensembl

ENSMUSG00000026707 (Evidence)
NCBI Gene

74455

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026707	Ensembl Gene Model \| MGI Sequence Detail	59939	C57BL/6J	± kb
transcript	ENSMUST00000076435	Ensembl \| MGI Sequence Detail	3042	Not Applicable
polypeptide	ENSMUSP00000075766	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029657 tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR002478 PUA domain

IPR036974 PUA domain superfamily

IPR015947 PUA-like superfamily

IPR023267 RNA (C5-cytosine) methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

IPR049560 SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core

IPR001678 SAM-dependent methyltransferase RsmB-F/NOP2-type domain

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All nucleic 22

cDNA 20

Primer pair 2

Microarray probesets 3

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MGI:1921099

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:337561 Wang W, et al., A Cross-Tissue Investigation of Molecular Targets and Physiological Functions of Nsun6 Using Knockout Mice. Int J Mol Sci. 2022 Jun 13;23(12)

TSS for Nsun6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22740	Chr2:15059870-15059890 (-)	0 bp
Tssr409	Chr2:15059846-15059860 (-)	27 bp
Tssr22739	Chr2:15054065-15054150 (-)	5,772 bp
Tssr22738	Chr2:15053987-15054009 (-)	5,882 bp
Tssr22737	Chr2:15053970-15053981 (-)	5,904 bp
Tssr22736	Chr2:15053927-15053937 (-)	5,948 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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