Pus10 MGI Mouse Gene Detail - MGI:1921717 - pseudouridylate synthase 10

Symbol

Pus10
Name

pseudouridylate synthase 10
Synonyms

2810013G11Rik, 4933435A13Rik, Ccdc139

Feature Type

protein coding gene
IDs

MGI:1921717
NCBI Gene: 74467
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:23615674-23682876 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.34 cM, cytoband A3.3
Mapping Data

3 experiments

SNPs within 2kb

1476 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921717	protein coding gene	Chr11:23608588-23682876 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018091	protein coding gene	Chr11:21437000-21508355 (+)
A/J	MGP_AJ_G0018064	protein coding gene	Chr11:20595718-20662841 (+)
AKR/J	MGP_AKRJ_G0018028	protein coding gene	Chr11:21331425-21399233 (+)
BALB/cJ	MGP_BALBcJ_G0018032	protein coding gene	Chr11:20736155-20802846 (+)
C3H/HeJ	MGP_C3HHeJ_G0017846	protein coding gene	Chr11:21215215-21283117 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018484	protein coding gene	Chr11:22294634-22363415 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016142	protein coding gene	Chr11:19496104-19561378 (+)
CAST/EiJ	MGP_CASTEiJ_G0017407	protein coding gene	Chr11:21241686-21311019 (+)
CBA/J	MGP_CBAJ_G0017820	protein coding gene	Chr11:23282024-23359740 (+)
DBA/2J	MGP_DBA2J_G0017930	protein coding gene	Chr11:20519581-20586924 (+)
FVB/NJ	MGP_FVBNJ_G0017922	protein coding gene	Chr11:20301853-20367927 (+)
LP/J	MGP_LPJ_G0018001	protein coding gene	Chr11:21526122-21595098 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017948	protein coding gene	Chr11:23816969-23891044 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018525	protein coding gene	Chr11:21445600-21513699 (+)
PWK/PhJ	MGP_PWKPhJ_G0017188	protein coding gene	Chr11:20568449-20637397 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016985	protein coding gene	Chr11:21188460-21254639 (+)
WSB/EiJ	MGP_WSBEiJ_G0017461	protein coding gene	Chr11:21076688-21146476 (+)

Human Ortholog

PUS10, pseudouridine synthase 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PUS10, pseudouridine synthase 10
Synonyms

CCDC139, DOBI, Hup10
Links

HGNC:26505

NCBI Gene ID: 150962

neXtProt AC: NX_Q3MIT2

UniProt: Q3MIT2
Chr Location

2p16.1-p15; chr2:60940222-61018259 (-) GRCh38

MGI Vertebrate Homology

Pus10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PUS10
Gene Tree

Pus10

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

19
Targeted

3
Genomic Mutations

1 involving Pus10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pus10

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All Sequences

105
RefSeq

52
UniProt

2
CCDS

CCDS24479.1

Ensembl

ENSMUSG00000020280 (Evidence)
NCBI Gene

74467

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020280	Ensembl Gene Model \| MGI Sequence Detail	67203	C57BL/6J	± kb
transcript	ENSMUST00000109525	Ensembl \| MGI Sequence Detail	3177	Not Applicable
polypeptide	ENSMUSP00000105151	Ensembl \| MGI Sequence Detail	527	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029702 tRNA pseudouridine synthase Pus10

(term hierarchy)
EC

5.4.99.25
InterPro Domains

IPR020103 Pseudouridine synthase, catalytic domain superfamily

IPR048741 Pus10-like, C-terminal

IPR048742 Pus10, N-terminal, eukaryotes

IPR039894 tRNA pseudouridine synthase Pus10-like

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All nucleic 18

cDNA 18

Microarray probesets 4

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MGI:1919873, MGI:2144364, MGI:2144627

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pus10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100631	Chr11:23615410-23615438 (+)	-250 bp
Tssr100632	Chr11:23615615-23615623 (+)	-55 bp
Tssr100633	Chr11:23616122-23616202 (+)	488 bp
Tssr100634	Chr11:23616205-23616225 (+)	541 bp
Tssr100635	Chr11:23616378-23616430 (+)	730 bp
Tssr100636	Chr11:23616479-23616496 (+)	814 bp
Tssr100637	Chr11:23649578-23649582 (+)	33,906 bp
Tssr100638	Chr11:23678822-23678828 (+)	63,151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24