Tnks2 MGI Mouse Gene Detail - MGI:1921743 - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Symbol

Tnks2
Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms

5430432P15Rik, Parp5b

Feature Type

protein coding gene
IDs

MGI:1921743
NCBI Gene: 74493
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:36811632-36870877 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 31.96 cM
Mapping Data

2 experiments

SNPs within 2kb

1348 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921743	protein coding gene	Chr19:36811583-36870877 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025074	protein coding gene	Chr19:35741048-35799968 (+)
A/J	MGP_AJ_G0025050	protein coding gene	Chr19:34031239-34091085 (+)
AKR/J	MGP_AKRJ_G0025018	protein coding gene	Chr19:35184182-35244836 (+)
BALB/cJ	MGP_BALBcJ_G0025048	protein coding gene	Chr19:34114262-34173349 (+)
C3H/HeJ	MGP_C3HHeJ_G0024807	protein coding gene	Chr19:35240358-35303882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025489	protein coding gene	Chr19:36773662-36837064 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022907	protein coding gene	Chr19:33399725-33456643 (+)
CAST/EiJ	MGP_CASTEiJ_G0024274	protein coding gene	Chr19:35070675-35135047 (+)
CBA/J	MGP_CBAJ_G0024784	protein coding gene	Chr19:38525110-38584329 (+)
DBA/2J	MGP_DBA2J_G0024916	protein coding gene	Chr19:33888670-33948107 (+)
FVB/NJ	MGP_FVBNJ_G0024877	protein coding gene	Chr19:33697077-33756369 (+)
LP/J	MGP_LPJ_G0025002	protein coding gene	Chr19:35838436-35906704 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024908	protein coding gene	Chr19:38341163-38407210 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025547	protein coding gene	Chr19:35270875-35331992 (+)
PWK/PhJ	MGP_PWKPhJ_G0024026	protein coding gene	Chr19:33715699-33777394 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023826	protein coding gene	Chr19:34096561-34157619 (+)
WSB/EiJ	MGP_WSBEiJ_G0024341	protein coding gene	Chr19:35363143-35424960 (+)

Human Ortholog

TNKS2, tankyrase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNKS2, tankyrase 2
Synonyms

ARTD6, PARP-5b, PARP5B, PARP-5c, PARP5C, pART6, TANK2, TNKL
Links

HGNC:15677

NCBI Gene ID: 80351

neXtProt AC: NX_Q9H2K2

UniProt: Q9H2K2
Chr Location

10q23.32; chr10:91798426-91865475 (+) GRCh38

MGI Vertebrate Homology

Tnks2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TNKS2
Gene Tree

Tnks2

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Phenotype Summary

8 phenotypes from 4 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

1
Gene trapped

18
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are viable but display decreased body weight and abnormal adipocyte glucose uptake in response to insulin stimulation. Mice homozygous for a different null allele show partial postnatal lethality as well as decreased body weight.

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All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

55
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnks2

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All Sequences

64
RefSeq

8
UniProt

5
CCDS

CCDS50426.1

Ensembl

ENSMUSG00000024811 (Evidence)
NCBI Gene

74493

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024811	Ensembl Gene Model \| MGI Sequence Detail	59246	C57BL/6J	± kb
transcript	ENSMUST00000249614	Ensembl \| MGI Sequence Detail	6481	Not Applicable
polypeptide	ENSMUSP00000159823	Ensembl \| MGI Sequence Detail	1180	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016499 poly [ADP-ribose] polymerase tankyrase-2

(term hierarchy)
EC

2.4.2.-, 2.4.2.30
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR050745 Multifunctional regulatory proteins

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 7

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MGI:2147446, MGI:2147590

Summaries

All 50

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346147 Hou S, et al., PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis. Mol Cell. 2024 Mar 7;84(5):938-954.e8

TSS for Tnks2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156197	Chr19:36810578-36810595 (+)	-1,045 bp
Tssr156198	Chr19:36811596-36811608 (+)	-30 bp
Tssr156199	Chr19:36811615-36811697 (+)	24 bp
Tssr156200	Chr19:36811704-36811709 (+)	75 bp
Tssr156201	Chr19:36856660-36856679 (+)	45,038 bp
Tssr156202	Chr19:36868191-36868214 (+)	56,571 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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