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Neto2 Gene Detail
Summary
  • Symbol
    Neto2
  • Name
    neuropilin (NRP) and tolloid (TLL)-like 2
  • Synonyms
    5530601C23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921763
    NCBI Gene: 74513
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:86363217-86427553 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.61 cM, cytoband C4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921763
 protein coding gene Chr8:86363217-86428011 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033904
 protein coding gene Chr8:86587752-86654719 (-)
A/J MGP_AJ_G0033887
 protein coding gene Chr8:83178477-83243605 (-)
AKR/J MGP_AKRJ_G0033813
 protein coding gene Chr8:85654041-85720151 (-)
BALB/cJ MGP_BALBcJ_G0033880
 protein coding gene Chr8:83320534-83384795 (-)
C3H/HeJ MGP_C3HHeJ_G0033591
 protein coding gene Chr8:86277013-86341065 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034401
 protein coding gene Chr8:89929396-89992297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031341
 protein coding gene Chr8:76966080-77026666 (-)
CAST/EiJ MGP_CASTEiJ_G0032921
 protein coding gene Chr8:85688401-85759876 (-)
CBA/J MGP_CBAJ_G0033566
 protein coding gene Chr8:92976188-93045138 (-)
DBA/2J MGP_DBA2J_G0033719
 protein coding gene Chr8:82815711-82878972 (-)
FVB/NJ MGP_FVBNJ_G0033667
 protein coding gene Chr8:81760836-81825419 (-)
LP/J MGP_LPJ_G0033811
 protein coding gene Chr8:86703971-86772241 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033710
 protein coding gene Chr8:95498177-95568430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034418
 protein coding gene Chr8:85638962-85706124 (-)
PWK/PhJ MGP_PWKPhJ_G0032625
 protein coding gene Chr8:82058717-82127021 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032460
 protein coding gene Chr8:84427050-84491656 (-)
WSB/EiJ MGP_WSBEiJ_G0033033
 protein coding gene Chr8:86063475-86131424 (-)



Homology
more
  • Human Ortholog
    NETO2, neuropilin and tolloid like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NETO2, neuropilin and tolloid like 2
  • Synonyms
    BTCL2, NEOT2
  • Links
    NCBI Gene ID: 81831
    neXtProt AC: NX_Q8NC67
    UniProt: Q8NC67

  • Chr Location
    16q12.1; chr16:47077703-47143945 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation show normal brain morphology and kainate receptor mediated excitatory postsynaptic currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    117
  • cDNA Data
    72
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036902 Ensembl Gene Model | MGI Sequence Detail 64337 C57BL/6J ±  kb
transcript ENSMUST00000109686 Ensembl | MGI Sequence Detail 5610 Not Applicable  
polypeptide ENSMUSP00000105308 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011144 neuropilin and tolloid-like protein 2
    (term hierarchy)
  • InterPro Domains
    IPR000859 CUB domain
    IPR050841 Developmental metalloproteases and endocytic receptors
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR035914 Spermadhesin, CUB domain superfamily
  • GlyGen
    Q8BNJ6 1 site
Molecular
Reagents
less
  • All nucleic 77
    cDNA 73
    Primer pair 2
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142645
References
more
  • Summaries
    All 88
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 51
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:353360 Cesari E, et al., Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory