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Ppp6r3 Gene Detail
Summary
  • Symbol
    Ppp6r3
  • Name
    protein phosphatase 6, regulatory subunit 3
  • Synonyms
    4930528G08Rik, 9130026N02Rik, D19Bwg1430e, D19Ertd703e, mKIAA1558, Pp6r3, Pptcs3, Saps3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921807
    NCBI Gene: 52036
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3504928-3625749 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.21 cM, cytoband A
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2331 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921807
 protein coding gene Chr19:3504928-3626191 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024626
 protein coding gene Chr19:215216-340244 (-)
A/J MGP_AJ_G0024593
 protein coding gene Chr19:223071-346254 (-)
AKR/J MGP_AKRJ_G0024564
 protein coding gene Chr19:210632-334351 (-)
BALB/cJ MGP_BALBcJ_G0024591
 protein coding gene Chr19:208614-330400 (-)
C3H/HeJ MGP_C3HHeJ_G0024360
 protein coding gene Chr19:213587-337426 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025039
 protein coding gene Chr19:203485-328695 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022468
 protein coding gene Chr19:201360-321802 (-)
CAST/EiJ MGP_CASTEiJ_G0023832
 protein coding gene Chr19:211156-344182 (-)
CBA/J MGP_CBAJ_G0024330
 protein coding gene Chr19:236795-371902 (-)
DBA/2J MGP_DBA2J_G0024459
 protein coding gene Chr19:204583-325516 (-)
FVB/NJ MGP_FVBNJ_G0024426
 protein coding gene Chr19:206088-329293 (-)
LP/J MGP_LPJ_G0024545
 protein coding gene Chr19:213217-339092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024456
 protein coding gene Chr19:222827-361759 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025087
 protein coding gene Chr19:203614-331513 (-)
PWK/PhJ MGP_PWKPhJ_G0023578
 protein coding gene Chr19:214475-337097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023384
 protein coding gene Chr19:203948-330523 (-)
WSB/EiJ MGP_WSBEiJ_G0023895
 protein coding gene Chr19:211893-333834 (-)



Homology
more
  • Human Ortholog
    PPP6R3, protein phosphatase 6 regulatory subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP6R3, protein phosphatase 6 regulatory subunit 3
  • Synonyms
    C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3
  • Links
    NCBI Gene ID: 55291
    neXtProt AC: NX_Q5H9R7
    UniProt: Q5H9R7

  • Chr Location
    11q13.2; chr11:68460731-68615334 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    284
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024908 Ensembl Gene Model | MGI Sequence Detail 120822 C57BL/6J ±  kb
transcript ENSMUST00000113997 Ensembl | MGI Sequence Detail 4952 Not Applicable  
polypeptide ENSMUSP00000109630 Ensembl | MGI Sequence Detail 873 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014453 serine/threonine-protein phosphatase 6 regulatory subunit 3
    (term hierarchy)
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR007587 SIT4 phosphatase-associated protein family
  • GlyGen
    Q922D4 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 287
    cDNA 284
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-33943, MGI:106251, MGI:1097687, MGI:1289228, MGI:1923074
References
more
  • Summaries
    All 48
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:42329 Saijoh Y, et al., Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1996 Feb;1(2):239-52
  • Latest
    J:336778 Yang Y, et al., SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice. Nat Commun. 2023 Mar 13;14(1):1368
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory