About   Help   FAQ
Tent5c Gene Detail
Summary
  • Symbol
    Tent5c
  • Name
    terminal nucleotidyltransferase 5C
  • Synonyms
    4930431B09Rik, Fam46c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921895
    NCBI Gene: 74645
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100375373-100396508 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921895
 protein coding gene Chr3:100358944-100396640 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027667
 protein coding gene Chr3:101568214-101605606 (-)
A/J MGP_AJ_G0027626
 protein coding gene Chr3:98358884-98397067 (-)
AKR/J MGP_AKRJ_G0027592
 protein coding gene Chr3:100742622-100781145 (-)
BALB/cJ MGP_BALBcJ_G0027639
 protein coding gene Chr3:98120022-98161708 (-)
C3H/HeJ MGP_C3HHeJ_G0027368
 protein coding gene Chr3:101063396-101106466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028082
 protein coding gene Chr3:105296063-105336865 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025423
 protein coding gene Chr3:94572412-94609874 (-)
CAST/EiJ MGP_CASTEiJ_G0026824
 protein coding gene Chr3:100172099-100212546 (-)
CBA/J MGP_CBAJ_G0027343
 protein coding gene Chr3:108900386-108938067 (-)
DBA/2J MGP_DBA2J_G0027486
 protein coding gene Chr3:97598972-97640886 (-)
FVB/NJ MGP_FVBNJ_G0027454
 protein coding gene Chr3:95541447-95579245 (-)
LP/J MGP_LPJ_G0027593
 protein coding gene Chr3:102920466-102959196 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027484
 protein coding gene Chr3:115156404-115196135 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028137
 protein coding gene Chr3:100253038-100292834 (-)
PWK/PhJ MGP_PWKPhJ_G0026551
 protein coding gene Chr3:97350360-97393641 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026373
 protein coding gene Chr3:98357657-98400556 (-)
WSB/EiJ MGP_WSBEiJ_G0026904
 protein coding gene Chr3:100816815-100857919 (-)



Homology
more
  • Human Ortholog
    TENT5C, terminal nucleotidyltransferase 5C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TENT5C, terminal nucleotidyltransferase 5C
  • Synonyms
    FAM46C
  • Links
    NCBI Gene ID: 54855
    neXtProt AC: NX_Q5VWP2
    UniProt: Q5VWP2

  • Chr Location
    1p12; chr1:117606048-117628389 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypochromic microcytic anemia and decreased B cell proliferation. Mice homozygous for a different allele exhibit male infertility associated with oligozoospermia and detachment of the head from flagellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    6
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74645 NCBI Gene Model | MGI Sequence Detail 21136 C57BL/6J ±  kb
    transcript NM_001142952 RefSeq | MGI Sequence Detail 2054 C57BL/6  
    polypeptide Q5SSF7 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139713, MGI:6155754
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory