Ptchd3 MGI Mouse Gene Detail - MGI:1921925 - patched domain containing 3

Symbol

Ptchd3
Name

patched domain containing 3
Synonyms

4930451E13Rik, 4933440L20Rik

Feature Type

protein coding gene
IDs

MGI:1921925
NCBI Gene: 74675
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:121721073-121734249 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 87.90 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

280 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921925	protein coding gene	Chr11:121721050-121734259 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019554	protein coding gene	Chr11:126387447-126400624 (+)
A/J	MGP_AJ_G0019521	protein coding gene	Chr11:120736719-120749895 (+)
AKR/J	MGP_AKRJ_G0019491	protein coding gene	Chr11:124404106-124417282 (+)
BALB/cJ	MGP_BALBcJ_G0019496	protein coding gene	Chr11:121116990-121130166 (+)
C3H/HeJ	MGP_C3HHeJ_G0019302	protein coding gene	Chr11:124733318-124746494 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019945	protein coding gene	Chr11:130217470-130230646 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017570	protein coding gene	Chr11:117726185-117739672 (+)
CAST/EiJ	MGP_CASTEiJ_G0018856	protein coding gene	Chr11:126224669-126238708 (+)
CBA/J	MGP_CBAJ_G0019273	protein coding gene	Chr11:135282206-135295382 (+)
DBA/2J	MGP_DBA2J_G0019386	protein coding gene	Chr11:120129247-120142485 (+)
FVB/NJ	MGP_FVBNJ_G0019377	protein coding gene	Chr11:119853885-119867302 (+)
LP/J	MGP_LPJ_G0019457	protein coding gene	Chr11:126675719-126688891 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019410	protein coding gene	Chr11:134060827-134074003 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019984	protein coding gene	Chr11:125097205-125110381 (+)
PWK/PhJ	MGP_PWKPhJ_G0018623	protein coding gene	Chr11:121560327-121582846 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018414	protein coding gene	Chr11:124829555-124856923 (+)
WSB/EiJ	MGP_WSBEiJ_G0018909	protein coding gene	Chr11:125055975-125069151 (+)

Human Ortholog

PTCHD3, patched domain containing 3 (gene/pseudogene)

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTCHD3, patched domain containing 3 (gene/pseudogene)
Synonyms

PTR
Links

HGNC:24776

NCBI Gene ID: 374308

neXtProt AC: NX_Q3KNS1

UniProt: Q3KNS1
Chr Location

10p12.1; chr10:27397121-27414368 (-) GRCh38

MGI Vertebrate Homology

Ptchd3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTCHD3
Gene Tree

Ptchd3

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and live normally into adulthood with no apparent defects in male fertility or spermatogenesis.

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All GO Annotations

8
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS49014.1

Ensembl

ENSMUSG00000039198 (Evidence)
NCBI Gene

74675

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039198	Ensembl Gene Model \| MGI Sequence Detail	13177	C57BL/6J	± kb
transcript	ENSMUST00000036690	Ensembl \| MGI Sequence Detail	3194	Not Applicable
polypeptide	ENSMUSP00000035709	Ensembl \| MGI Sequence Detail	906	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013414 patched domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR051697 Patched domain-containing protein

IPR003392 Protein patched/dispatched

IPR000731 Sterol-sensing domain
GlyGen

Q0EEE2 2 sites

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All nucleic 5

cDNA 5

Microarray probesets 2

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MGI:1914032

Summaries

All 32

Gene Ontology 7

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ptchd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106434	Chr11:121721019-121721024 (+)	-51 bp
Tssr106435	Chr11:121721041-121721050 (+)	-27 bp
Tssr106436	Chr11:121721057-121721076 (+)	-6 bp
Tssr106437	Chr11:121721080-121721105 (+)	20 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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