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C2cd5 Gene Detail
Summary
  • Symbol
    C2cd5
  • Name
    C2 calcium-dependent domain containing 5
  • Synonyms
    5730419I09Rik, C030008B15Rik, CDP138
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921991
    NCBI Gene: 74741
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:142956646-143045867 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 75.13 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921991
 protein coding gene Chr6:142956646-143045878 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031472
 protein coding gene Chr6:147840084-147933971 (-)
A/J MGP_AJ_G0031447
 protein coding gene Chr6:142032967-142121714 (-)
AKR/J MGP_AKRJ_G0031375
 protein coding gene Chr6:146246198-146337486 (-)
BALB/cJ MGP_BALBcJ_G0031454
 protein coding gene Chr6:141797484-141887255 (-)
C3H/HeJ MGP_C3HHeJ_G0031176
 protein coding gene Chr6:146281716-146373201 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031916
 protein coding gene Chr6:151883813-151977202 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029040
 protein coding gene Chr6:140845185-140935227 (-)
CAST/EiJ MGP_CASTEiJ_G0030544
 protein coding gene Chr6:145876069-145971986 (-)
CBA/J MGP_CBAJ_G0031136
 protein coding gene Chr6:157659802-157756823 (-)
DBA/2J MGP_DBA2J_G0031293
 protein coding gene Chr6:140856495-140945420 (-)
FVB/NJ MGP_FVBNJ_G0031244
 protein coding gene Chr6:139590856-139681597 (-)
LP/J MGP_LPJ_G0031377
 protein coding gene Chr6:147982738-148075944 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031284
 protein coding gene Chr6:161537400-161637187 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031948
 protein coding gene Chr6:146089449-146184285 (-)
PWK/PhJ MGP_PWKPhJ_G0030271
 protein coding gene Chr6:139335190-139430203 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030095
 protein coding gene Chr6:144271338-144365851 (-)
WSB/EiJ MGP_WSBEiJ_G0030637
 protein coding gene Chr6:146690519-146782325 (-)



Homology
more
  • Human Ortholog
    C2CD5, C2 calcium dependent domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C2CD5, C2 calcium dependent domain containing 5
  • Synonyms
    CDP138, KIAA0528
  • Links
    NCBI Gene ID: 9847
    neXtProt AC: NX_Q86YS7
    UniProt: Q86YS7

  • Chr Location
    12p12.1; chr12:22448583-22544546 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have altered catecholamine levels, exhibit energy imbalance and obesity due to impaired fat browning, lipolysis, fatty acid oxidation and thermogenesis, and develop insulin resistance and impaired glucose metabolism in response to high-fat diet feeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    139
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030279 Ensembl Gene Model | MGI Sequence Detail 89222 C57BL/6J ±  kb
    transcript ENSMUST00000203673 Ensembl | MGI Sequence Detail 3332 Not Applicable  
    polypeptide ENSMUSP00000145425 Ensembl | MGI Sequence Detail 1052 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 139

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924564
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:292159 Gavini CK, et al., Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance. Metabolism. 2020 Jan;102:153990
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory