Ddit4 MGI Mouse Gene Detail - MGI:1921997 - DNA-damage-inducible transcript 4

Symbol

Ddit4
Name

DNA-damage-inducible transcript 4
Synonyms

5830413E08Rik, Dig2, REDD1, Rtp801

Feature Type

protein coding gene
IDs

MGI:1921997
NCBI Gene: 74747
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:59785497-59787592 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.66 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

67 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921997	protein coding gene	Chr10:59785491-59787656 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017262	protein coding gene	Chr10:59145830-59147925 (-)
A/J	MGP_AJ_G0017240	protein coding gene	Chr10:57413278-57415373 (-)
AKR/J	MGP_AKRJ_G0017200	protein coding gene	Chr10:58904248-58906343 (-)
BALB/cJ	MGP_BALBcJ_G0017200	protein coding gene	Chr10:57503182-57505277 (-)
C3H/HeJ	MGP_C3HHeJ_G0017023	protein coding gene	Chr10:58824979-58827074 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017658	protein coding gene	Chr10:61263772-61265867 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015349	protein coding gene	Chr10:54430040-54432126 (-)
CAST/EiJ	MGP_CASTEiJ_G0016594	protein coding gene	Chr10:58755902-58757988 (-)
CBA/J	MGP_CBAJ_G0016995	protein coding gene	Chr10:63451895-63453990 (-)
DBA/2J	MGP_DBA2J_G0017100	protein coding gene	Chr10:56723337-56725432 (-)
FVB/NJ	MGP_FVBNJ_G0017094	protein coding gene	Chr10:55958379-55960474 (-)
LP/J	MGP_LPJ_G0017175	protein coding gene	Chr10:59519007-59521102 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017122	protein coding gene	Chr10:65954600-65956695 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017696	protein coding gene	Chr10:58713967-58716062 (-)
PWK/PhJ	MGP_PWKPhJ_G0016377	protein coding gene	Chr10:56526943-56529029 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016160	protein coding gene	Chr10:58043025-58045112 (-)
WSB/EiJ	MGP_WSBEiJ_G0016658	protein coding gene	Chr10:58618817-58620912 (-)

Human Ortholog

DDIT4, DNA damage inducible transcript 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDIT4, DNA damage inducible transcript 4
Synonyms

Dig2, REDD-1, REDD1
Links

HGNC:24944

NCBI Gene ID: 54541

neXtProt AC: NX_Q9NX09

UniProt: Q9NX09
Chr Location

10q22.1; chr10:72273919-72276036 (+) GRCh38

MGI Vertebrate Homology

Ddit4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDIT4
Gene Tree

Ddit4

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Phenotype Summary

7 phenotypes from 4 alleles in 4 genetic backgrounds
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

11
Gene trapped

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Ddit4
Incidental Mutations

CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show resistance to hyperoxia-induced retinopathy. Mice homozygous for another knock-out allele exhibit normal testis development and fertility.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

23
cDNA Data

100
Literature Summary

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddit4

ZFIN ddit4

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS23868.1

Ensembl

ENSMUSG00000020108 (Evidence)
NCBI Gene

74747

			Length	Strain/Species	Flank
genomic	74747	NCBI Gene Model \| MGI Sequence Detail	2096	C57BL/6J	± kb
transcript	NM_029083	RefSeq \| MGI Sequence Detail	1685	C57BL/6
polypeptide	Q9D3F7	UniProt \| EBI \| MGI Sequence Detail	229	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006348 DNA damage-inducible transcript 4 protein

(term hierarchy)
InterPro Domains

IPR012918 RTP801-like

IPR038281 RTP801-like, C-terminal domain superfamily

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All nucleic 105

Genomic 2

cDNA 101

Primer pair 2

Microarray probesets 3

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MGI:2143476

Summaries

All 104

Developmental Gene Expression 11

Gene Ontology 10

Phenotypes 52
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918

TSS for Ddit4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97688	Chr10:59787646-59787662 (-)	-62 bp
Tssr97687	Chr10:59787575-59787597 (-)	6 bp
Tssr97686	Chr10:59787553-59787564 (-)	33 bp
Tssr97685	Chr10:59787369-59787381 (-)	217 bp
Tssr97684	Chr10:59787339-59787350 (-)	247 bp
Tssr97683	Chr10:59787303-59787319 (-)	281 bp
Tssr97682	Chr10:59786038-59786050 (-)	1,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24