Slamf8 MGI Mouse Gene Detail - MGI:1921998

Symbol

Slamf8
Name

SLAM family member 8
Synonyms

5830408F06Rik, Blame, SBBI42

Feature Type

protein coding gene
IDs

MGI:1921998
NCBI Gene: 74748
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:172409325-172418135 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.99 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

374 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921998	protein coding gene	Chr1:172408944-172418482 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016793	protein coding gene	Chr1:178455487-178466362 (-)
A/J	MGP_AJ_G0016772	protein coding gene	Chr1:171167983-171176737 (-)
AKR/J	MGP_AKRJ_G0016738	protein coding gene	Chr1:176328207-176338542 (-)
BALB/cJ	MGP_BALBcJ_G0016733	protein coding gene	Chr1:171698142-171706904 (-)
C3H/HeJ	MGP_C3HHeJ_G0016557	protein coding gene	Chr1:176901419-176910189 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017195	protein coding gene	Chr1:184381544-184391715 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014901	protein coding gene	Chr1:162852723-162861735 (-)
CAST/EiJ	MGP_CASTEiJ_G0016137	protein coding gene	Chr1:176270241-176279687 (-)
CBA/J	MGP_CBAJ_G0016531	protein coding gene	Chr1:190932518-190945464 (-)
DBA/2J	MGP_DBA2J_G0016638	protein coding gene	Chr1:170085584-170094876 (-)
FVB/NJ	MGP_FVBNJ_G0016635	protein coding gene	Chr1:168345687-168354451 (-)
LP/J	MGP_LPJ_G0016709	protein coding gene	Chr1:179538807-179548971 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016662	protein coding gene	Chr1:198162161-198172265 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017231	protein coding gene	Chr1:176200367-176209096 (-)
PWK/PhJ	MGP_PWKPhJ_G0015923	protein coding gene	Chr1:169470142-169478954 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015705	protein coding gene	Chr1:175157937-175166751 (-)
WSB/EiJ	MGP_WSBEiJ_G0016199	protein coding gene	Chr1:176349201-176359506 (-)

Human Ortholog

SLAMF8, SLAM family member 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLAMF8, SLAM family member 8
Synonyms

BLAME, CD353, SBBI42
Links

HGNC:21391

NCBI Gene ID: 56833

neXtProt AC: NX_Q9P0V8

UniProt: Q9P0V8
Chr Location

1q23.2; chr1:159826811-159837492 (+) GRCh38

MGI Vertebrate Homology

Slamf8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLAMF8
Gene Tree

Slamf8

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

2 involving Slamf8
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele exhibit increased Nox2 activity in macrophage.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slamf8

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All Sequences

39
RefSeq

4
UniProt

4
CCDS

CCDS15517.1

Ensembl

ENSMUSG00000053318 (Evidence)
NCBI Gene

74748

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053318	Ensembl Gene Model \| MGI Sequence Detail	8811	C57BL/6J	± kb
transcript	ENSMUST00000065679	Ensembl \| MGI Sequence Detail	1659	Not Applicable
polypeptide	ENSMUSP00000067527	Ensembl \| MGI Sequence Detail	278	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014914 SLAM family member 8

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold
GlyGen

Q9D3G2 2 sites

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All nucleic 10

cDNA 10

Microarray probesets 2

Summaries

All 31

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:317677 Zeng X, et al., Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages. Cell Mol Immunol. 2020 Feb;17(2):153-162

TSS for Slamf8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15243	Chr1:172418234-172418246 (-)	-105 bp
Tssr15242	Chr1:172418217-172418233 (-)	-90 bp
Tssr15241	Chr1:172418189-172418212 (-)	-66 bp
Tssr15240	Chr1:172418155-172418173 (-)	-29 bp
Tssr15239	Chr1:172418058-172418148 (-)	32 bp
Tssr15238	Chr1:172418044-172418056 (-)	85 bp
Tssr15237	Chr1:172418030-172418042 (-)	99 bp
Tssr15236	Chr1:172416136-172416180 (-)	1,977 bp
Tssr15235	Chr1:172415800-172415813 (-)	2,328 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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