Mxra8 MGI Mouse Gene Detail - MGI:1922011 - matrix-remodelling associated 8

Symbol

Mxra8
Name

matrix-remodelling associated 8
Synonyms

1200013A08Rik, Asp3, DICAM, limitrin

Feature Type

protein coding gene
IDs

MGI:1922011
NCBI Gene: 74761
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr4:155924137-155928545 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 87.58 cM, cytoband E2
Mapping Data

4 experiments

SNPs within 2kb

234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922011	protein coding gene	Chr4:155924137-155928559 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029232	protein coding gene	Chr4:160209602-160213972 (+)
A/J	MGP_AJ_G0029197	protein coding gene	Chr4:153457977-153462328 (+)
AKR/J	MGP_AKRJ_G0029145	protein coding gene	Chr4:157637097-157641431 (+)
BALB/cJ	MGP_BALBcJ_G0029213	protein coding gene	Chr4:153932039-153936356 (+)
C3H/HeJ	MGP_C3HHeJ_G0028934	protein coding gene	Chr4:158179595-158183962 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029662	protein coding gene	Chr4:165885196-165891504 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026907	protein coding gene	Chr4:145746030-145750412 (+)
CAST/EiJ	MGP_CASTEiJ_G0028346	protein coding gene	Chr4:155650233-155655534 (+)
CBA/J	MGP_CBAJ_G0028896	protein coding gene	Chr4:170902187-170906547 (+)
DBA/2J	MGP_DBA2J_G0029045	protein coding gene	Chr4:153479191-153483511 (+)
FVB/NJ	MGP_FVBNJ_G0029008	protein coding gene	Chr4:152728475-152732846 (+)
LP/J	MGP_LPJ_G0029135	protein coding gene	Chr4:160137900-160142236 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029035	protein coding gene	Chr4:173715891-173720263 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029694	protein coding gene	Chr4:158263101-158267490 (+)
PWK/PhJ	MGP_PWKPhJ_G0028067	protein coding gene	Chr4:149622587-149626942 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027901	protein coding gene	Chr4:152521931-152526259 (+)
WSB/EiJ	MGP_WSBEiJ_G0028426	protein coding gene	Chr4:158436146-158441520 (+)

Human Ortholog

MXRA8, matrix remodeling associated 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MXRA8, matrix remodeling associated 8
Synonyms

ASP3
Links

HGNC:7542

NCBI Gene ID: 54587

neXtProt AC: NX_Q9BRK3

UniProt: Q9BRK3
Chr Location

1p36.33; chr1:1352689-1363541 (-) GRCh38

MGI Vertebrate Homology

Mxra8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MXRA8
Gene Tree

Mxra8

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Phenotype Summary

7 phenotypes from 4 alleles in 4 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

6
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested in a high-throughput screen. Mice homozygous for two alleles with intragenic deletions in the Ig-like domain 2 show decreased infection of musculoskeletal tissues with various alphaviruses.

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All GO Annotations

9
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

17
cDNA Data

66
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mxra8

ZFIN mxra8a, mxra8b

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All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS19044.1

Ensembl

ENSMUSG00000029070 (Evidence)
NCBI Gene

74761

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029070	Ensembl Gene Model \| MGI Sequence Detail	4409	C57BL/6J	± kb
transcript	ENSMUST00000030947	Ensembl \| MGI Sequence Detail	2203	Not Applicable
polypeptide	ENSMUSP00000030947	Ensembl \| MGI Sequence Detail	442	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010796 matrix remodeling-associated protein 8

(term hierarchy)
PDB

6JO7, 6NK3, 6NK6, 6NK7, 8EWF, 8SQN
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR042472 Matrix remodeling-associated protein 8
GlyGen

Q9DBV4 2 sites, 3 N-linked glycans (2 sites)

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All nucleic 68

Genomic 1

cDNA 66

Other 1

Microarray probesets 3

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MGI:1920805, MGI:2140196

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346715 Holmes AC, et al., Ly6C(+) monocytes in the skin promote systemic alphavirus dissemination. Cell Rep. 2024 Mar 26;43(3):113876

TSS for Mxra8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40724	Chr4:155924132-155924141 (+)	0 bp
Tssr40725	Chr4:155924150-155924161 (+)	19 bp
Tssr40726	Chr4:155924181-155924219 (+)	63 bp
Tssr40727	Chr4:155924226-155924281 (+)	117 bp
Tssr40728	Chr4:155924284-155924297 (+)	154 bp
Tssr40729	Chr4:155925558-155925565 (+)	1,425 bp
Tssr40730	Chr4:155925578-155925595 (+)	1,450 bp
Tssr40731	Chr4:155925603-155925624 (+)	1,477 bp
Tssr40732	Chr4:155925625-155925632 (+)	1,492 bp
Tssr40733	Chr4:155925869-155925933 (+)	1,764 bp
Tssr40734	Chr4:155927508-155927557 (+)	3,396 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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