Ppa2 MGI Mouse Gene Detail - MGI:1922026 - pyrophosphatase (inorganic) 2

Symbol

Ppa2
Name

pyrophosphatase (inorganic) 2
Synonyms

1110013G13Rik, Sid6306

Feature Type

protein coding gene
IDs

MGI:1922026
NCBI Gene: 74776
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:133015871-133083996 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 61.71 cM
Mapping Data

1 experiment

SNPs within 2kb

2199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922026	protein coding gene	Chr3:133015842-133083996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027898	protein coding gene	Chr3:136098793-136171568 (+)
A/J	MGP_AJ_G0027856	protein coding gene	Chr3:131301179-131370565 (+)
AKR/J	MGP_AKRJ_G0027821	protein coding gene	Chr3:134723849-134800245 (+)
BALB/cJ	MGP_BALBcJ_G0027869	protein coding gene	Chr3:131146245-131218897 (+)
C3H/HeJ	MGP_C3HHeJ_G0027598	protein coding gene	Chr3:135109050-135184607 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028312	protein coding gene	Chr3:140854034-140919515 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025650	protein coding gene	Chr3:126726521-126800672 (+)
CAST/EiJ	MGP_CASTEiJ_G0027054	protein coding gene	Chr3:134880993-134982963 (+)
CBA/J	MGP_CBAJ_G0027574	protein coding gene	Chr3:145635468-145706588 (+)
DBA/2J	MGP_DBA2J_G0027714	protein coding gene	Chr3:130465231-130532998 (+)
FVB/NJ	MGP_FVBNJ_G0027681	protein coding gene	Chr3:128056471-128124582 (+)
LP/J	MGP_LPJ_G0027824	protein coding gene	Chr3:137579977-137653173 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027712	protein coding gene	Chr3:153628421-153698277 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028370	protein coding gene	Chr3:134380873-134449335 (+)
PWK/PhJ	MGP_PWKPhJ_G0026778	protein coding gene	Chr3:130229618-130330137 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026603	protein coding gene	Chr3:132443157-132544987 (+)
WSB/EiJ	MGP_WSBEiJ_G0027133	protein coding gene	Chr3:135148542-135217966 (+)

Human Ortholog

PPA2, inorganic pyrophosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPA2, inorganic pyrophosphatase 2
Synonyms

HSPC124, SCFAI, SCFI, SID6-306
Links

HGNC:28883

NCBI Gene ID: 27068

neXtProt AC: NX_Q9H2U2

UniProt: Q9H2U2
Chr Location

4q24; chr4:105369077-105474070 (-) GRCh38

MGI Vertebrate Homology

Ppa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPA2
Gene Tree

Ppa2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Genomic Mutations

2 involving Ppa2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

69
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppa2

ZFIN ppa2

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All Sequences

54
RefSeq

14
UniProt

3
CCDS

CCDS17850.1, CCDS80024.1

Ensembl

ENSMUSG00000028013 (Evidence)
NCBI Gene

74776

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028013	Ensembl Gene Model \| MGI Sequence Detail	68126	C57BL/6J	± kb
transcript	ENSMUST00000029644	Ensembl \| MGI Sequence Detail	1226	Not Applicable
polypeptide	ENSMUSP00000029644	Ensembl \| MGI Sequence Detail	330	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013049 inorganic pyrophosphatase 2, mitochondrial

(term hierarchy)
EC

3.6.1.1
InterPro Domains

IPR008162 Inorganic pyrophosphatase

IPR036649 Inorganic pyrophosphatase superfamily
GlyGen

Q91VM9 1 site, 1 O-linked glycan (1 site)

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All nucleic 69

cDNA 69

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 1

Diseases 1

Gene Ontology 9

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31773	Chr3:133015849-133015852 (+)	-20 bp
Tssr31774	Chr3:133015854-133015906 (+)	9 bp
Tssr31775	Chr3:133015925-133015930 (+)	57 bp
Tssr31776	Chr3:133015942-133015979 (+)	90 bp
Tssr31777	Chr3:133026685-133026729 (+)	10,836 bp
Tssr31778	Chr3:133044705-133044732 (+)	28,848 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24