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Ppa2 Gene Detail
Summary
  • Symbol
    Ppa2
  • Name
    pyrophosphatase (inorganic) 2
  • Synonyms
    1110013G13Rik, Sid6306
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922026
    NCBI Gene: 74776
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:133015871-133083996 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 61.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922026
protein coding gene Chr3:133015842-133083996 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027898
protein coding gene Chr3:136098793-136171568 (+)
A/J MGP_AJ_G0027856
protein coding gene Chr3:131301179-131370565 (+)
AKR/J MGP_AKRJ_G0027821
protein coding gene Chr3:134723849-134800245 (+)
BALB/cJ MGP_BALBcJ_G0027869
protein coding gene Chr3:131146245-131218897 (+)
C3H/HeJ MGP_C3HHeJ_G0027598
protein coding gene Chr3:135109050-135184607 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028312
protein coding gene Chr3:140854034-140919515 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025650
protein coding gene Chr3:126726521-126800672 (+)
CAST/EiJ MGP_CASTEiJ_G0027054
protein coding gene Chr3:134880993-134982963 (+)
CBA/J MGP_CBAJ_G0027574
protein coding gene Chr3:145635468-145706588 (+)
DBA/2J MGP_DBA2J_G0027714
protein coding gene Chr3:130465231-130532998 (+)
FVB/NJ MGP_FVBNJ_G0027681
protein coding gene Chr3:128056471-128124582 (+)
LP/J MGP_LPJ_G0027824
protein coding gene Chr3:137579977-137653173 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027712
protein coding gene Chr3:153628421-153698277 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028370
protein coding gene Chr3:134380873-134449335 (+)
PWK/PhJ MGP_PWKPhJ_G0026778
protein coding gene Chr3:130229618-130330137 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026603
protein coding gene Chr3:132443157-132544987 (+)
WSB/EiJ MGP_WSBEiJ_G0027133
protein coding gene Chr3:135148542-135217966 (+)



Homology
more
  • Human Ortholog
    PPA2, inorganic pyrophosphatase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPA2, inorganic pyrophosphatase 2
  • Synonyms
    HSPC124, SCFAI, SCFI, SID6-306
  • Links
    NCBI Gene ID: 27068
    neXtProt AC: NX_Q9H2U2
    UniProt: Q9H2U2

  • Chr Location
    4q24; chr4:105369077-105474070 (-)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028013 Ensembl Gene Model | MGI Sequence Detail 68126 C57BL/6J ±  kb
transcript ENSMUST00000029644 Ensembl | MGI Sequence Detail 1226 Not Applicable  
polypeptide ENSMUSP00000029644 Ensembl | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory