Slc45a3 MGI Mouse Gene Detail - MGI:1922082 - solute carrier family 45, member 3

Symbol

Slc45a3
Name

solute carrier family 45, member 3
Synonyms

2210413P12Rik, IPCA-6, MGC:32471, Pcanap6

Feature Type

protein coding gene
IDs

MGI:1922082
NCBI Gene: 212980
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:131890705-131910707 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.24 cM
Mapping Data

2 experiments

SNPs within 2kb

483 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922082	protein coding gene	Chr1:131890653-131910710 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016463	protein coding gene	Chr1:135414798-135434858 (+)
A/J	MGP_AJ_G0016446	protein coding gene	Chr1:130405039-130425061 (+)
AKR/J	MGP_AKRJ_G0016411	protein coding gene	Chr1:134233240-134253254 (+)
BALB/cJ	MGP_BALBcJ_G0016406	protein coding gene	Chr1:130724716-130744743 (+)
C3H/HeJ	MGP_C3HHeJ_G0016232	protein coding gene	Chr1:134381076-134401074 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016867	protein coding gene	Chr1:140458781-140478815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014578	protein coding gene	Chr1:123548097-123568127 (+)
CAST/EiJ	MGP_CASTEiJ_G0015812	protein coding gene	Chr1:133382484-133402271 (+)
CBA/J	MGP_CBAJ_G0016204	protein coding gene	Chr1:145237459-145257482 (+)
DBA/2J	MGP_DBA2J_G0016311	protein coding gene	Chr1:129368477-129388489 (+)
FVB/NJ	MGP_FVBNJ_G0016310	protein coding gene	Chr1:127991774-128011785 (+)
LP/J	MGP_LPJ_G0016382	protein coding gene	Chr1:136728904-136748907 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016335	protein coding gene	Chr1:151021552-151042452 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016903	protein coding gene	Chr1:133993866-134013702 (+)
PWK/PhJ	MGP_PWKPhJ_G0015598	protein coding gene	Chr1:128338394-128358850 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015385	protein coding gene	Chr1:132940487-132960531 (+)
WSB/EiJ	MGP_WSBEiJ_G0015874	protein coding gene	Chr1:133978222-133999497 (+)

Human Ortholog

SLC45A3, solute carrier family 45 member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC45A3, solute carrier family 45 member 3
Synonyms

IPCA-2, IPCA-6, IPCA6, IPCA-8, PCANAP2, PCANAP6, PCANAP8, PRST
Links

HGNC:8642

NCBI Gene ID: 85414

neXtProt AC: NX_Q96JT2

UniProt: Q96JT2
Chr Location

1q32.1; chr1:205657851-205680509 (-) GRCh38

MGI Vertebrate Homology

Slc45a3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC45A3
Gene Tree

Slc45a3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Slc45a3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

943
Tissues

130
cDNA Data

107
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc45a3

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All Sequences

51
RefSeq

8
UniProt

2
CCDS

CCDS15278.1

Ensembl

ENSMUSG00000026435 (Evidence)
NCBI Gene

212980

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026435	Ensembl Gene Model \| MGI Sequence Detail	20003	C57BL/6J	± kb
transcript	ENSMUST00000177943	Ensembl \| MGI Sequence Detail	3212	Not Applicable
polypeptide	ENSMUSP00000136190	Ensembl \| MGI Sequence Detail	553	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031722 solute carrier family 45 member 3

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR036259 MFS transporter superfamily

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All nucleic 108

cDNA 107

Primer pair 1

Microarray probesets 5

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MGI:2138476, MGI:2138500

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc45a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8696	Chr1:131890725-131890739 (+)	27 bp
Tssr8697	Chr1:131897646-131897650 (+)	6,943 bp
Tssr8698	Chr1:131898293-131898310 (+)	7,597 bp
Tssr8699	Chr1:131898327-131898339 (+)	7,628 bp
Tssr8700	Chr1:131902031-131902079 (+)	11,350 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24