Meikin MGI Mouse Gene Detail - MGI:1922097 - meiotic kinetochore factor

Symbol

Meikin
Name

meiotic kinetochore factor
Synonyms

4930404A10Rik

Feature Type

protein coding gene
IDs

MGI:1922097
NCBI Gene: 74847
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:54261478-54317616 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM, cytoband B1.3
Mapping Data

2 experiments

SNPs within 2kb

1467 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922097	protein coding gene	Chr11:54261478-54317616 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018315	protein coding gene	Chr11:53843682-53898928 (+)
A/J	MGP_AJ_G0018284	protein coding gene	Chr11:51835224-51888435 (+)
AKR/J	MGP_AKRJ_G0018253	protein coding gene	Chr11:53535895-53591327 (+)
BALB/cJ	MGP_BALBcJ_G0018255	protein coding gene	Chr11:52178346-52228444 (+)
C3H/HeJ	MGP_C3HHeJ_G0018066	protein coding gene	Chr11:53479057-53524561 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018707	protein coding gene	Chr11:55500051-55554440 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016357	protein coding gene	Chr11:49296543-49334903 (+)
CAST/EiJ	MGP_CASTEiJ_G0017631	protein coding gene	Chr11:53516448-53572209 (+)
CBA/J	MGP_CBAJ_G0018041	protein coding gene	Chr11:58132933-58186687 (+)
DBA/2J	MGP_DBA2J_G0018150	protein coding gene	Chr11:51547671-51600976 (+)
FVB/NJ	MGP_FVBNJ_G0018142	protein coding gene	Chr11:51191143-51248687 (+)
LP/J	MGP_LPJ_G0018225	protein coding gene	Chr11:54297747-54352928 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018168	protein coding gene	Chr11:59333233-59384903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018749	protein coding gene	Chr11:53548135-53601379 (+)
PWK/PhJ	MGP_PWKPhJ_G0017404	protein coding gene	Chr11:52091256-52139461 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017199	protein coding gene	Chr11:53330057-53379870 (+)
WSB/EiJ	MGP_WSBEiJ_G0017679	protein coding gene	Chr11:53181438-53235600 (+)

Human Ortholog

MEIKIN, meiotic kinetochore factor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEIKIN, meiotic kinetochore factor
Synonyms

SPO13
Links

HGNC:51253

NCBI Gene ID: 728637

neXtProt AC: NX_A0A087WXM9

UniProt: A0A087WXM9
Chr Location

5q31.1; chr5:131806990-131945698 (-) GRCh38

MGI Vertebrate Homology

Meikin stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MEIKIN
Gene Tree

Meikin

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

1
Genomic Mutations

1 involving Meikin
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display male and female infertility with defects in sister kinetochore pairing in meiosis I.

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All GO Annotations

16
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS48798.1

Ensembl

ENSMUSG00000020332 (Evidence)
NCBI Gene

74847

			Length	Strain/Species	Flank
genomic	74847	NCBI Gene Model \| MGI Sequence Detail	56139	C57BL/6J	± kb
transcript	NM_029105	RefSeq \| MGI Sequence Detail	1482	C57BL/6
polypeptide	Q5F2C3	UniProt \| EBI \| MGI Sequence Detail	434	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059648 meiosis-specific kinetochore protein

(term hierarchy)
InterPro Domains

IPR034545 Meiosis-specific kinetochore protein

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All nucleic 10

cDNA 10

Microarray probesets 2

Summaries

All 23

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 5
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:307864 Horisawa-Takada Y, et al., Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nat Commun. 2021 Jun 1;12(1):3184

TSS for Meikin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101490	Chr11:54261424-54261439 (+)	-46 bp
Tssr101491	Chr11:54261442-54261449 (+)	-32 bp
Tssr101492	Chr11:54261451-54261458 (+)	-23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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