Ccdc181 MGI Mouse Gene Detail - MGI:1922145 - coiled-coil domain containing 181

Symbol

Ccdc181
Name

coiled-coil domain containing 181
Synonyms

4930455F23Rik

Feature Type

protein coding gene
IDs

MGI:1922145
NCBI Gene: 74895
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:164103154-164115416 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 71.59 cM, cytoband H1
Mapping Data

3 experiments

SNPs within 2kb

365 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922145	protein coding gene	Chr1:164103126-164115416 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016682	protein coding gene	Chr1:169711567-169723825 (+)
A/J	MGP_AJ_G0016663	protein coding gene	Chr1:162781153-162793415 (+)
AKR/J	MGP_AKRJ_G0016629	protein coding gene	Chr1:167720170-167732422 (+)
BALB/cJ	MGP_BALBcJ_G0016624	protein coding gene	Chr1:163285016-163297270 (+)
C3H/HeJ	MGP_C3HHeJ_G0016448	protein coding gene	Chr1:167916307-167928573 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017085	protein coding gene	Chr1:175397602-175409864 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014794	protein coding gene	Chr1:154762351-154774780 (+)
CAST/EiJ	MGP_CASTEiJ_G0016028	protein coding gene	Chr1:167552670-167564937 (+)
CBA/J	MGP_CBAJ_G0016423	protein coding gene	Chr1:181649610-181661864 (+)
DBA/2J	MGP_DBA2J_G0016529	protein coding gene	Chr1:161674716-161687107 (+)
FVB/NJ	MGP_FVBNJ_G0016527	protein coding gene	Chr1:160135803-160148016 (+)
LP/J	MGP_LPJ_G0016600	protein coding gene	Chr1:170792198-170804468 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016552	protein coding gene	Chr1:189142507-189154738 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017121	protein coding gene	Chr1:167563456-167575699 (+)
PWK/PhJ	MGP_PWKPhJ_G0015814	protein coding gene	Chr1:160865559-160878300 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015601	protein coding gene	Chr1:166432561-166445001 (+)
WSB/EiJ	MGP_WSBEiJ_G0016090	protein coding gene	Chr1:167716749-167729029 (+)

Human Ortholog

CCDC181, coiled-coil domain containing 181

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC181, coiled-coil domain containing 181
Synonyms

C1orf114
Links

HGNC:28051

NCBI Gene ID: 57821

neXtProt AC: NX_Q5TID7

UniProt: Q5TID7
Chr Location

1q24.2; chr1:169394870-169460669 (-) GRCh38

MGI Vertebrate Homology

Ccdc181 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCDC181
Gene Tree

Ccdc181

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Genomic Mutations

2 involving Ccdc181
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile, with defective late spermatids that undergo apoptosis and lead to a decline in sperm counts. Sperm show defective head shaping, acrosome detachment, impaired manchette formation, and defects in sperm flagellum and motility.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

3
cDNA Data

37
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc181

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS15434.1

Ensembl

ENSMUSG00000026578 (Evidence)
NCBI Gene

74895

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026578	Ensembl Gene Model \| MGI Sequence Detail	12263	C57BL/6J	± kb
transcript	ENSMUST00000027867	Ensembl \| MGI Sequence Detail	1909	Not Applicable
polypeptide	ENSMUSP00000027867	Ensembl \| MGI Sequence Detail	509	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000059832 coiled-coil domain-containing protein 181

(term hierarchy)
InterPro Domains

IPR026687 Coiled-coil domain-containing protein 181

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All nucleic 37

cDNA 37

Microarray probesets 2

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MGI:2138234

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:359010 Zhang XJ, et al., CCDC181 is required for sperm flagellum biogenesis and male fertility in mice. Zool Res. 2024 Sep 18;45(5):1061-1072

TSS for Ccdc181:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9776	Chr1:164103128-164103229 (+)	25 bp
Tssr9777	Chr1:164103238-164103255 (+)	93 bp
Tssr9778	Chr1:164103258-164103271 (+)	111 bp
Tssr9779	Chr1:164105672-164105695 (+)	2,530 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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