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Stk38l Gene Detail
Summary
  • Symbol
    Stk38l
  • Name
    serine/threonine kinase 38 like
  • Synonyms
    4930473A22Rik, Ndr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922250
    NCBI Gene: 232533
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:146626493-146680310 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922250
 protein coding gene Chr6:146626428-146680312 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031490
 protein coding gene Chr6:151746159-151802885 (+)
A/J MGP_AJ_G0031465
 protein coding gene Chr6:145735159-145792036 (+)
AKR/J MGP_AKRJ_G0031393
 protein coding gene Chr6:150057291-150121012 (+)
BALB/cJ MGP_BALBcJ_G0031473
 protein coding gene Chr6:145473843-145545495 (+)
C3H/HeJ MGP_C3HHeJ_G0031194
 protein coding gene Chr6:150122265-150180794 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031934
 protein coding gene Chr6:155802781-155859338 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029058
 protein coding gene Chr6:144451550-144533245 (+)
CAST/EiJ MGP_CASTEiJ_G0030563
 protein coding gene Chr6:149757855-149819467 (+)
CBA/J MGP_CBAJ_G0031154
 protein coding gene Chr6:161742652-161798717 (+)
DBA/2J MGP_DBA2J_G0031310
 protein coding gene Chr6:144516879-144572191 (+)
FVB/NJ MGP_FVBNJ_G0031262
 protein coding gene Chr6:143250682-143311915 (+)
LP/J MGP_LPJ_G0031396
 protein coding gene Chr6:151834305-151892495 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031302
 protein coding gene Chr6:165473037-165533185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031967
 protein coding gene Chr6:149889173-149949251 (+)
PWK/PhJ MGP_PWKPhJ_G0030289
 protein coding gene Chr6:143034813-143090394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030113
 protein coding gene Chr6:148043589-148104842 (+)
WSB/EiJ MGP_WSBEiJ_G0030656
 protein coding gene Chr6:150512075-150568209 (+)



Homology
more
  • Human Ortholog
    STK38L, serine/threonine kinase 38 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK38L, serine/threonine kinase 38 like
  • Synonyms
    NDR2
  • Links
    NCBI Gene ID: 23012
    neXtProt AC: NX_Q9Y2H1
    UniProt: Q9Y2H1

  • Chr Location
    12p11.23; chr12:27243968-27325959 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous gene-trapped mice exhibit premature dendritic branching of CA3 pyramidal neurons. Mice homozygous for a knock-out allele exhibit mislocalization of opsin, increased apoptosis and proliferation of interneurons in the inner nuclear layer and disrupted localization of amacrine cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001630 Ensembl Gene Model | MGI Sequence Detail 53818 C57BL/6J ±  kb
    transcript ENSMUST00000111644 Ensembl | MGI Sequence Detail 2274 Not Applicable  
    polypeptide ENSMUSP00000107271 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 6
    References
    more
    • Summaries
      All 45
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350068 Rosianu F, et al., Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration. Life Sci Alliance. 2023 Feb;6(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory