Mindy1 MGI Mouse Gene Detail - MGI:1922257 - MINDY lysine 48 deubiquitinase 1

Symbol

Mindy1
Name

MINDY lysine 48 deubiquitinase 1
Synonyms

1810005H09Rik, 4930504E06Rik, cI-40, Fam63a, mKIAA1390, NF-E2 inducible protein

Feature Type

protein coding gene
IDs

MGI:1922257
NCBI Gene: 75007
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr3:95189237-95203477 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

379 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922257	protein coding gene	Chr3:95188656-95203477 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027580	protein coding gene	Chr3:95999012-96014425 (+)
A/J	MGP_AJ_G0027539	protein coding gene	Chr3:93023136-93037957 (+)
AKR/J	MGP_AKRJ_G0027506	protein coding gene	Chr3:95173760-95188595 (+)
BALB/cJ	MGP_BALBcJ_G0027551	protein coding gene	Chr3:92801436-92816257 (+)
C3H/HeJ	MGP_C3HHeJ_G0027284	protein coding gene	Chr3:95457103-95471919 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027999	protein coding gene	Chr3:99561094-99576697 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025339	protein coding gene	Chr3:89387389-89402601 (+)
CAST/EiJ	MGP_CASTEiJ_G0026734	protein coding gene	Chr3:94745917-94765260 (+)
CBA/J	MGP_CBAJ_G0027261	protein coding gene	Chr3:103173617-103191542 (+)
DBA/2J	MGP_DBA2J_G0027400	protein coding gene	Chr3:92315487-92330307 (+)
FVB/NJ	MGP_FVBNJ_G0027371	protein coding gene	Chr3:90390817-90406179 (+)
LP/J	MGP_LPJ_G0027509	protein coding gene	Chr3:97300951-97316424 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027398	protein coding gene	Chr3:109283161-109297982 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028053	protein coding gene	Chr3:94828893-94844045 (+)
PWK/PhJ	MGP_PWKPhJ_G0026462	protein coding gene	Chr3:92196269-92212110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026283	protein coding gene	Chr3:93126603-93141727 (+)
WSB/EiJ	MGP_WSBEiJ_G0026816	protein coding gene	Chr3:95217060-95231786 (+)

Human Ortholog

MINDY1, MINDY lysine 48 deubiquitinase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MINDY1, MINDY lysine 48 deubiquitinase 1
Synonyms

FAM63A, MINDY-1
Links

HGNC:25648

NCBI Gene ID: 55793

neXtProt AC: NX_Q8N5J2

UniProt: Q8N5J2
Chr Location

1q21.3; chr1:150996536-151008393 (-) GRCh38

MGI Vertebrate Homology

Mindy1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MINDY1
Gene Tree

Mindy1

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

88
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

81
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Mindy1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

24

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mindy1

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All Sequences

109
RefSeq

16
UniProt

6
CCDS

CCDS17611.1, CCDS57233.1

Ensembl

ENSMUSG00000038712 (Evidence)
NCBI Gene

75007

			Length	Strain/Species	Flank
genomic	75007	NCBI Gene Model \| MGI Sequence Detail	14241	C57BL/6J	± kb
transcript	NM_199475	RefSeq \| MGI Sequence Detail	2850	C57BL/6
polypeptide	Q76LS9	UniProt \| EBI \| MGI Sequence Detail	468	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000032167 ubiquitin carboxyl-terminal hydrolase MINDY-1

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR007518 MINDY deubiquitinase

IPR033979 MINDY deubiquitinase domain

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All nucleic 25

cDNA 25

Microarray probesets 8

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MGI:1916272, MGI:1930769, MGI:2139610, MGI:3034747, MGI:5897436

Summaries

All 49

Diseases 1

Gene Ontology 6

Phenotypes 17
Earliest

J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mindy1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30516	Chr3:95188639-95188659 (+)	-588 bp
Tssr30517	Chr3:95188669-95188702 (+)	-551 bp
Tssr30518	Chr3:95189785-95189807 (+)	559 bp
Tssr30519	Chr3:95189809-95189866 (+)	601 bp
Tssr30520	Chr3:95189898-95189916 (+)	670 bp
Tssr30521	Chr3:95190208-95190253 (+)	994 bp
Tssr30522	Chr3:95190260-95190269 (+)	1,028 bp
Tssr30523	Chr3:95190273-95190284 (+)	1,042 bp
Tssr30524	Chr3:95190308-95190321 (+)	1,078 bp
Tssr30525	Chr3:95190324-95190367 (+)	1,109 bp
Tssr30526	Chr3:95190385-95190423 (+)	1,167 bp
Tssr30527	Chr3:95190437-95190451 (+)	1,207 bp
Tssr30528	Chr3:95190475-95190499 (+)	1,250 bp
Tssr30529	Chr3:95190507-95190519 (+)	1,276 bp
Tssr30530	Chr3:95190520-95190533 (+)	1,290 bp
Tssr30531	Chr3:95190574-95190605 (+)	1,353 bp
Tssr30532	Chr3:95190634-95190644 (+)	1,402 bp
Tssr30533	Chr3:95190706-95190717 (+)	1,475 bp
Tssr30534	Chr3:95190755-95190828 (+)	1,555 bp
Tssr30535	Chr3:95194049-95194093 (+)	4,834 bp
Tssr30536	Chr3:95194951-95194965 (+)	5,721 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24