Sv2c MGI Mouse Gene Detail - MGI:1922459 - synaptic vesicle glycoprotein 2c

Symbol

Sv2c
Name

synaptic vesicle glycoprotein 2c
Synonyms

4930527L09Rik

Feature Type

protein coding gene
IDs

MGI:1922459
NCBI Gene: 75209
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr13:96091102-96269085 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 50.47 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

6362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922459	protein coding gene	Chr13:96091102-96270837 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020846	protein coding gene	Chr13:97456301-97640404 (-)
A/J	MGP_AJ_G0020800	protein coding gene	Chr13:93797292-93974190 (-)
AKR/J	MGP_AKRJ_G0020774	protein coding gene	Chr13:96660802-96850924 (-)
BALB/cJ	MGP_BALBcJ_G0020797	protein coding gene	Chr13:94476487-94656463 (-)
C3H/HeJ	MGP_C3HHeJ_G0020590	protein coding gene	Chr13:96354073-96540907 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021233	protein coding gene	Chr13:100407054-100610992 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018802	protein coding gene	Chr13:89609917-89790573 (-)
CAST/EiJ	MGP_CASTEiJ_G0020109	protein coding gene	Chr13:95661903-95849576 (-)
CBA/J	MGP_CBAJ_G0020549	protein coding gene	Chr13:104386763-104580101 (-)
DBA/2J	MGP_DBA2J_G0020674	protein coding gene	Chr13:93572140-93752801 (-)
FVB/NJ	MGP_FVBNJ_G0020655	protein coding gene	Chr13:92353555-92532315 (-)
LP/J	MGP_LPJ_G0020749	protein coding gene	Chr13:97573048-97777973 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020683	protein coding gene	Chr13:104815934-105007110 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021273	protein coding gene	Chr13:96064797-96261572 (-)
PWK/PhJ	MGP_PWKPhJ_G0019861	protein coding gene	Chr13:92357099-92540291 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019685	protein coding gene	Chr13:92350362-92543403 (-)
WSB/EiJ	MGP_WSBEiJ_G0020166	protein coding gene	Chr13:96563108-96749016 (-)

Human Ortholog

SV2C, synaptic vesicle glycoprotein 2C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SV2C, synaptic vesicle glycoprotein 2C
Synonyms

SLC22B3
Links

HGNC:30670

NCBI Gene ID: 22987

neXtProt AC: NX_Q496J9

UniProt: Q496J9
Chr Location

5q13.3; chr5:75847464-76353939 (+) GRCh38

MGI Vertebrate Homology

Sv2c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SV2C
Gene Tree

Sv2c

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

3
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available

Mice homozygous for a knock-out allele exhibit hypoactivity and increased anxiety-related response.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

835
Tissues

112
cDNA Data

8
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

6
UniProt

3
CCDS

CCDS49333.1

Ensembl

ENSMUSG00000051111 (Evidence)
NCBI Gene

75209

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051111	Ensembl Gene Model \| MGI Sequence Detail	177984	C57BL/6J	± kb
transcript	ENSMUST00000161263	Ensembl \| MGI Sequence Detail	9101	Not Applicable
polypeptide	ENSMUSP00000124473	Ensembl \| MGI Sequence Detail	727	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015851 synaptic vesicle glycoprotein 2C

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR001646 Pentapeptide repeat

IPR005829 Sugar transporter, conserved site

IPR022308 Synaptic vesicle protein SV2
GlyGen

Q69ZS6 6 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

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MGI:2145291

Summaries

All 55

Developmental Gene Expression 14

Gene Ontology 7

Phenotypes 13
Earliest

J:36947 Ahnert-Hilger G, et al., Synaptobrevin is essential for secretion but not for the development of synaptic processes. Eur J Cell Biol. 1996 May;70(1):1-11
Latest

J:347652 Bucher ML, et al., Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. Eur J Neurosci. 2024 Mar 26;

TSS for Sv2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123558	Chr13:96269208-96269219 (-)	-129 bp
Tssr123557	Chr13:96269177-96269195 (-)	-101 bp
Tssr123556	Chr13:96269076-96269136 (-)	-21 bp
Tssr123555	Chr13:96269051-96269075 (-)	22 bp
Tssr123554	Chr13:96269029-96269038 (-)	51 bp
Tssr123551	Chr13:96147542-96147550 (-)	121,539 bp
Tssr123550	Chr13:96098161-96098180 (-)	170,914 bp
Tssr123549	Chr13:96098085-96098095 (-)	170,995 bp
Tssr123548	Chr13:96097993-96098002 (-)	171,087 bp
Tssr123547	Chr13:96094118-96094120 (-)	174,966 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24