Cep128 MGI Mouse Gene Detail - MGI:1922466

Symbol

Cep128
Name

centrosomal protein 128
Synonyms

4930534B04Rik, 5430424K18Rik

Feature Type

protein coding gene
IDs

MGI:1922466
NCBI Gene: 75216
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr12:90965266-91351183 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 44.08 cM, cytoband E
Mapping Data

3 experiments

SNPs within 2kb

10974 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922466	protein coding gene	Chr12:90965264-91351207 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019997	protein coding gene	Chr12:92130319-92511645 (-)
A/J	MGP_AJ_G0019952	protein coding gene	Chr12:88675920-89038211 (-)
AKR/J	MGP_AKRJ_G0019928	protein coding gene	Chr12:91045634-91434912 (-)
BALB/cJ	MGP_BALBcJ_G0019938	protein coding gene	Chr12:88964759-89325710 (-)
C3H/HeJ	MGP_C3HHeJ_G0019740	protein coding gene	Chr12:91668888-92038893 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020387	protein coding gene	Chr12:94839914-95238176 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018001	protein coding gene	Chr12:86156739-86496694 (-)
CAST/EiJ	MGP_CASTEiJ_G0019287	protein coding gene	Chr12:86584703-86954092 (-)
CBA/J	MGP_CBAJ_G0019712	protein coding gene	Chr12:98399393-98815522 (-)
DBA/2J	MGP_DBA2J_G0019823	protein coding gene	Chr12:88148962-88513113 (-)
FVB/NJ	MGP_FVBNJ_G0019812	protein coding gene	Chr12:87018916-87382036 (-)
LP/J	MGP_LPJ_G0019899	protein coding gene	Chr12:91915837-92305578 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019853	protein coding gene	Chr12:101175565-101588209 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020416	protein coding gene	Chr12:90664320-91051266 (-)
PWK/PhJ	MGP_PWKPhJ_G0019050	protein coding gene	Chr12:82735744-83093749 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018846	protein coding gene	Chr12:84836177-85200122 (-)
WSB/EiJ	MGP_WSBEiJ_G0019340	protein coding gene	Chr12:91402713-91778190 (-)

Human Ortholog

CEP128, centrosomal protein 128

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP128, centrosomal protein 128
Synonyms

C14orf145, C14orf61, LEDP/132
Links

HGNC:20359

NCBI Gene ID: 145508

neXtProt AC: NX_Q6ZU80

UniProt: Q6ZU80
Chr Location

14q31.1; chr14:80476969-80959517 (-) GRCh38

MGI Vertebrate Homology

Cep128 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: CEP128
Gene Tree

Cep128

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Phenotype Summary

20 phenotypes from 4 alleles in 4 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Genomic Mutations

1 involving Cep128
Incidental Mutations

APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility associated with impairs ciliogenesis in sperm, oligozoospermia, asthenozoospermia, and teratozoospermia.

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All GO Annotations

21
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

48

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep128

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All Sequences

78
RefSeq

19
UniProt

6
CCDS

CCDS36515.2

Ensembl

ENSMUSG00000061533 (Evidence)
NCBI Gene

75216

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061533	Ensembl Gene Model \| MGI Sequence Detail	385918	C57BL/6J	± kb
transcript	ENSMUST00000141429	Ensembl \| MGI Sequence Detail	4807	Not Applicable
polypeptide	ENSMUSP00000115679	Ensembl \| MGI Sequence Detail	1102	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000031345 centrosomal protein of 128 kDa

(term hierarchy)
InterPro Domains

IPR026652 Centrosomal protein of 128kDa
GlyGen

Q8BI22 1 site, 1 O-linked glycan (1 site)

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All nucleic 51

cDNA 51

Microarray probesets 6

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MGI:1918637, MGI:2144828, MGI:2144845

Summaries

All 32

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:323071 Zhang X, et al., CEP128 is involved in spermatogenesis in humans and mice. Nat Commun. 2022 Mar 16;13(1):1395

TSS for Cep128:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117207	Chr12:91351177-91351204 (-)	-8 bp
Tssr117206	Chr12:91351144-91351171 (-)	25 bp
Tssr117205	Chr12:91351120-91351134 (-)	56 bp
Tssr117204	Chr12:91351085-91351110 (-)	85 bp
Tssr3912	Chr12:91324106-91324112 (-)	27,074 bp
Tssr117203	Chr12:91296993-91296996 (-)	54,188 bp
Tssr117202	Chr12:91232830-91232833 (-)	118,351 bp
Tssr117201	Chr12:91182542-91182546 (-)	168,639 bp
Tssr117200	Chr12:91077026-91077029 (-)	274,155 bp
Tssr117199	Chr12:91066484-91066489 (-)	284,696 bp
Tssr117198	Chr12:91030149-91030163 (-)	321,027 bp
Tssr117197	Chr12:91007357-91007388 (-)	343,810 bp
Tssr117196	Chr12:90996844-90996877 (-)	354,322 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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