Dusp18 MGI Mouse Gene Detail - MGI:1922469 - dual specificity phosphatase 18

Symbol

Dusp18
Name

dual specificity phosphatase 18
Synonyms

4930527G07Rik, DSP18, DUSP20, LMWDSP20

Feature Type

protein coding gene
IDs

MGI:1922469
NCBI Gene: 75219
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:3845240-3851296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.74 cM
Mapping Data

2 experiments

SNPs within 2kb

219 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922469	protein coding gene	Chr11:3844940-3851299 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017965	protein coding gene	Chr11:805401-812579 (+)
A/J	MGP_AJ_G0017938	protein coding gene	Chr11:828356-834443 (+)
AKR/J	MGP_AKRJ_G0017902	protein coding gene	Chr11:855486-863443 (+)
BALB/cJ	MGP_BALBcJ_G0017906	protein coding gene	Chr11:793004-799051 (+)
C3H/HeJ	MGP_C3HHeJ_G0017719	protein coding gene	Chr11:784154-790256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018359	protein coding gene	Chr11:875399-882743 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016018	protein coding gene	Chr11:724383-730607 (+)
CAST/EiJ	MGP_CASTEiJ_G0017281	protein coding gene	Chr11:753124-760249 (+)
CBA/J	MGP_CBAJ_G0017694	protein coding gene	Chr11:1084481-1090582 (+)
DBA/2J	MGP_DBA2J_G0017805	protein coding gene	Chr11:734342-740655 (+)
FVB/NJ	MGP_FVBNJ_G0017796	protein coding gene	Chr11:770975-777504 (+)
LP/J	MGP_LPJ_G0017875	protein coding gene	Chr11:886498-894391 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017822	protein coding gene	Chr11:790002-796113 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018398	protein coding gene	Chr11:874529-880575 (+)
PWK/PhJ	MGP_PWKPhJ_G0017062	protein coding gene	Chr11:727263-733786 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016858	protein coding gene	Chr11:830351-836502 (+)
WSB/EiJ	MGP_WSBEiJ_G0017335	protein coding gene	Chr11:755088-762154 (+)

Human Ortholog

DUSP18, dual specificity phosphatase 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP18, dual specificity phosphatase 18
Synonyms

DSP18, DUSP20, LMWDSP20
Links

HGNC:18484

NCBI Gene ID: 150290

neXtProt AC: NX_Q8NEJ0

UniProt: Q8NEJ0
Chr Location

22q12.2; chr22:30652051-30667887 (-) GRCh38

MGI Vertebrate Homology

Dusp18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP18
Gene Tree

Dusp18

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

45
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

907
Tissues

128
cDNA Data

60
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS24369.1

Ensembl

ENSMUSG00000047205 (Evidence)
NCBI Gene

75219

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047205	Ensembl Gene Model \| MGI Sequence Detail	6057	C57BL/6J	± kb
transcript	ENSMUST00000109996	Ensembl \| MGI Sequence Detail	2685	Not Applicable
polypeptide	ENSMUSP00000105624	Ensembl \| MGI Sequence Detail	188	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006744 dual specificity protein phosphatase 18

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR020420 Atypical dual specificity phosphatase, subfamily B

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR016130 Protein-tyrosine phosphatase, active site

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 61

cDNA 60

Primer pair 1

Microarray probesets 6

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MGI:2144161, MGI:2144595

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:354130 Zhou X, et al., Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer. Nat Commun. 2024 Jul 12;15(1):5851

TSS for Dusp18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100068	Chr11:3845223-3845310 (+)	27 bp
Tssr100069	Chr11:3845318-3845329 (+)	84 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24