Rnf19b MGI Mouse Gene Detail - MGI:1922484

Symbol

Rnf19b
Name

ring finger protein 19B
Synonyms

4930534K13Rik, 4930555L03Rik, Ibrdc3

Feature Type

protein coding gene
IDs

MGI:1922484
NCBI Gene: 75234
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr4:128951871-128978319 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 62.76 cM, cytoband D2.3
Mapping Data

2 experiments

SNPs within 2kb

336 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922484	protein coding gene	Chr4:128951871-128979679 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028811	protein coding gene	Chr4:130911209-130939908 (+)
A/J	MGP_AJ_G0028770	protein coding gene	Chr4:125729954-125757400 (+)
AKR/J	MGP_AKRJ_G0028723	protein coding gene	Chr4:129212609-129246843 (+)
BALB/cJ	MGP_BALBcJ_G0028793	protein coding gene	Chr4:126311131-126339100 (+)
C3H/HeJ	MGP_C3HHeJ_G0028507	protein coding gene	Chr4:129266047-129294582 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029235	protein coding gene	Chr4:135868704-135900948 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026508	protein coding gene	Chr4:118860000-118887542 (+)
CAST/EiJ	MGP_CASTEiJ_G0027940	protein coding gene	Chr4:127437126-127467952 (+)
CBA/J	MGP_CBAJ_G0028473	protein coding gene	Chr4:139185905-139215194 (+)
DBA/2J	MGP_DBA2J_G0028622	protein coding gene	Chr4:126159258-126186991 (+)
FVB/NJ	MGP_FVBNJ_G0028589	protein coding gene	Chr4:124911263-124942108 (+)
LP/J	MGP_LPJ_G0028723	protein coding gene	Chr4:131224541-131251975 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028615	protein coding gene	Chr4:144095811-144125030 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029273	protein coding gene	Chr4:129581334-129608919 (+)
PWK/PhJ	MGP_PWKPhJ_G0027661	protein coding gene	Chr4:122731297-122758170 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027488	protein coding gene	Chr4:125441152-125469842 (+)
WSB/EiJ	MGP_WSBEiJ_G0028020	protein coding gene	Chr4:129689585-129718523 (+)

Human Ortholog

RNF19B, ring finger protein 19B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF19B, ring finger protein 19B
Synonyms

IBRDC3, NKLAM
Links

HGNC:26886

NCBI Gene ID: 127544

neXtProt AC: NX_Q6ZMZ0

UniProt: Q6ZMZ0
Chr Location

1p35.1; chr1:32929036-32964809 (-) GRCh38

MGI Vertebrate Homology

Rnf19b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF19B
Gene Tree

Rnf19b

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Rnf19b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and an impaired ability to control introduced tumor cells.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf19b

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All Sequences

54
RefSeq

6
UniProt

8
CCDS

CCDS51305.1, CCDS89829.1

Ensembl

ENSMUSG00000028793 (Evidence)
NCBI Gene

75234

			Length	Strain/Species	Flank
genomic	75234	NCBI Gene Model \| MGI Sequence Detail	26449	C57BL/6J	± kb
transcript	NM_001368763	RefSeq \| MGI Sequence Detail	2662	C57BL/6
polypeptide	A2A7Q9	UniProt \| EBI \| MGI Sequence Detail	732	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014114 E3 ubiquitin-protein ligase RNF19B

(term hierarchy)
EC

2.3.2.31
InterPro Domains

IPR031127 E3 ubiquitin ligase RBR family

IPR002867 IBR domain

IPR044066 TRIAD supradomain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:1922517

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf19b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39101	Chr4:128951868-128951884 (+)	5 bp
Tssr39102	Chr4:128951891-128951915 (+)	32 bp
Tssr39103	Chr4:128951926-128951945 (+)	65 bp
Tssr39104	Chr4:128952111-128952135 (+)	252 bp
Tssr39105	Chr4:128959911-128959914 (+)	8,042 bp
Tssr39106	Chr4:128964280-128964293 (+)	12,416 bp
Tssr39107	Chr4:128964297-128964310 (+)	12,433 bp
Tssr39108	Chr4:128964337-128964362 (+)	12,479 bp
Tssr39109	Chr4:128965954-128965958 (+)	14,085 bp
Tssr39110	Chr4:128971259-128971262 (+)	19,390 bp
Tssr39111	Chr4:128974287-128974299 (+)	22,422 bp
Tssr39112	Chr4:128974300-128974314 (+)	22,436 bp
Tssr39113	Chr4:128976533-128976553 (+)	24,672 bp
Tssr39114	Chr4:128976625-128976639 (+)	24,761 bp
Tssr39115	Chr4:128977674-128977698 (+)	25,815 bp
Tssr39116	Chr4:128977840-128977858 (+)	25,978 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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