Mphosph8 MGI Mouse Gene Detail - MGI:1922589

Symbol

Mphosph8
Name

M-phase phosphoprotein 8
Synonyms

1500035L22Rik, 4930548G07Rik

Feature Type

protein coding gene
IDs

MGI:1922589
NCBI Gene: 75339
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:56905705-56934887 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.37 cM
Mapping Data

2 experiments

SNPs within 2kb

611 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922589	protein coding gene	Chr14:56905692-56934887 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021396	protein coding gene	Chr14:50762868-50793047 (+)
A/J	MGP_AJ_G0021355	protein coding gene	Chr14:49753054-49782194 (+)
AKR/J	MGP_AKRJ_G0021331	protein coding gene	Chr14:51559310-51588411 (+)
BALB/cJ	MGP_BALBcJ_G0021358	protein coding gene	Chr14:49743758-49773105 (+)
C3H/HeJ	MGP_C3HHeJ_G0021139	protein coding gene	Chr14:51197660-51226784 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021798	protein coding gene	Chr14:53290922-53323298 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019340	protein coding gene	Chr14:47911198-47943379 (+)
CAST/EiJ	MGP_CASTEiJ_G0020658	protein coding gene	Chr14:47521934-47551543 (+)
CBA/J	MGP_CBAJ_G0021106	protein coding gene	Chr14:54874940-54906796 (+)
DBA/2J	MGP_DBA2J_G0021226	protein coding gene	Chr14:49469604-49499243 (+)
FVB/NJ	MGP_FVBNJ_G0021209	protein coding gene	Chr14:48863966-48893068 (+)
LP/J	MGP_LPJ_G0021301	protein coding gene	Chr14:51832882-51863243 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021233	protein coding gene	Chr14:54267488-54296944 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021824	protein coding gene	Chr14:50690099-50719115 (+)
PWK/PhJ	MGP_PWKPhJ_G0020401	protein coding gene	Chr14:45991896-46021531 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020231	protein coding gene	Chr14:46751602-46778426 (+)
WSB/EiJ	MGP_WSBEiJ_G0020710	protein coding gene	Chr14:51028020-51057014 (+)

Human Ortholog

MPHOSPH8, M-phase phosphoprotein 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPHOSPH8, M-phase phosphoprotein 8
Synonyms

HSMPP8, mpp8, TWA3
Links

HGNC:29810

NCBI Gene ID: 54737

neXtProt AC: NX_Q99549

UniProt: Q99549
Chr Location

13q12.11; chr13:19633659-19673441 (+) GRCh38

MGI Vertebrate Homology

Mphosph8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MPHOSPH8
Gene Tree

Mphosph8

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Targeted

4
Genomic Mutations

1 involving Mphosph8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality prior to E11.5. Mice homozygous for a null allele activated in neurons exhibit increased brain size, altered brain architecture, and behavioral changes.

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All GO Annotations

27
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mphosph8

ZFIN mphosph8

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All Sequences

67
RefSeq

10
UniProt

7
CCDS

CCDS49504.1

Ensembl

ENSMUSG00000079184 (Evidence)
NCBI Gene

75339

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079184	Ensembl Gene Model \| MGI Sequence Detail	29183	C57BL/6J	± kb
transcript	ENSMUST00000116468	Ensembl \| MGI Sequence Detail	2939	Not Applicable
polypeptide	ENSMUSP00000112170	Ensembl \| MGI Sequence Detail	858	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010538 M-phase phosphoprotein 8

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR000953 Chromo/chromo shadow domain

IPR023780 Chromo domain

IPR023779 Chromo domain, conserved site

IPR017984 Chromo domain subgroup

IPR016197 Chromo-like domain superfamily

IPR051219 Heterochromatin-associated chromo domain-containing protein

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All nucleic 18

Genomic 1

cDNA 17

Microarray probesets 6

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MGI:1925617, MGI:2145753

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mphosph8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125847	Chr14:56905699-56905806 (+)	48 bp
Tssr125848	Chr14:56909858-56909870 (+)	4,159 bp
Tssr125849	Chr14:56909916-56909930 (+)	4,218 bp
Tssr125850	Chr14:56911372-56911385 (+)	5,674 bp
Tssr125851	Chr14:56912080-56912083 (+)	6,377 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24