Arhgap36 MGI Mouse Gene Detail - MGI:1922654 - Rho GTPase activating protein 36

Symbol

Arhgap36
Name

Rho GTPase activating protein 36
Synonyms

1100001E04Rik

Feature Type

protein coding gene
IDs

MGI:1922654
NCBI Gene: 75404
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:48552822-48589121 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 25.95 cM
Mapping Data

1 experiment

SNPs within 2kb

512 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922654	protein coding gene	ChrX:48537237-48589121 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035701	protein coding gene	ChrX:44635651-44672653 (+)
A/J	MGP_AJ_G0035684	protein coding gene	ChrX:44458118-44494330 (+)
AKR/J	MGP_AKRJ_G0035604	protein coding gene	ChrX:45708797-45748555 (+)
BALB/cJ	MGP_BALBcJ_G0035670	protein coding gene	ChrX:44093631-44129753 (+)
C3H/HeJ	MGP_C3HHeJ_G0035374	protein coding gene	ChrX:44913082-44949356 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036199	protein coding gene	ChrX:45662290-45698557 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033051	protein coding gene	ChrX:42119440-42155516 (+)
CAST/EiJ	MGP_CASTEiJ_G0034665	protein coding gene	ChrX:32458053-32498762 (+)
CBA/J	MGP_CBAJ_G0035348	protein coding gene	ChrX:46982208-47018551 (+)
DBA/2J	MGP_DBA2J_G0035502	protein coding gene	ChrX:44317976-44356323 (+)
FVB/NJ	MGP_FVBNJ_G0035451	protein coding gene	ChrX:44030201-44066372 (+)
LP/J	MGP_LPJ_G0035590	protein coding gene	ChrX:44993311-45029568 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035489	protein coding gene	ChrX:48417689-48454542 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036217	protein coding gene	ChrX:44529283-44571031 (+)
PWK/PhJ	MGP_PWKPhJ_G0034364	protein coding gene	ChrX:31922226-31958816 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034209	protein coding gene	ChrX:33278123-33321779 (+)
WSB/EiJ	MGP_WSBEiJ_G0034809	protein coding gene	ChrX:44134028-44171301 (+)

Human Ortholog

ARHGAP36, Rho GTPase activating protein 36

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP36, Rho GTPase activating protein 36
Links

HGNC:26388

NCBI Gene ID: 158763

neXtProt AC: NX_Q6ZRI8

UniProt: Q6ZRI8
Chr Location

Xq26.1; chrX:131058346-131089885 (+) GRCh38

MGI Vertebrate Homology

Arhgap36 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGAP36
Gene Tree

Arhgap36

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

4 strains or lines available

Inactivation of this gene results in specific reduction of lateral motor column motor neurons in the developing embryonic spinal cord.

less

All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

11
cDNA Data

4
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN arhgap36

less

All Sequences

52
RefSeq

14
UniProt

3
CCDS

CCDS40963.1

Ensembl

ENSMUSG00000036198 (Evidence)
NCBI Gene

75404

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036198	Ensembl Gene Model \| MGI Sequence Detail	36300	C57BL/6J	± kb
transcript	ENSMUST00000114904	Ensembl \| MGI Sequence Detail	3033	Not Applicable
polypeptide	ENSMUSP00000110554	Ensembl \| MGI Sequence Detail	590	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000032027 Rho GTPase-activating protein 36

(term hierarchy)
InterPro Domains

IPR041852 ARHGAP6/36, RhoGAP domain

IPR037863 Rho GTPase-activating protein 6/36

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

less

All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 3

Summaries

All 28

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgap36:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160922	ChrX:48552803-48552850 (+)	5 bp
Tssr160923	ChrX:48559409-48559425 (+)	6,595 bp
Tssr160924	ChrX:48559432-48559456 (+)	6,622 bp
Tssr160925	ChrX:48573965-48573999 (+)	21,160 bp
Tssr160926	ChrX:48581982-48581991 (+)	29,165 bp
Tssr160927	ChrX:48581993-48582016 (+)	29,183 bp
Tssr160928	ChrX:48582019-48582051 (+)	29,213 bp
Tssr160929	ChrX:48587933-48587945 (+)	35,117 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24