Anapc15 MGI Mouse Gene Detail - MGI:1922680 - anaphase promoting complex C subunit 15

Symbol

Anapc15
Name

anaphase promoting complex C subunit 15
Synonyms

3200002M19Rik, 6330414C15Rik

Feature Type

protein coding gene
IDs

MGI:1922680
NCBI Gene: 75430
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:101530508-101551056 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.68 cM
Mapping Data

2 experiments

SNPs within 2kb

568 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922680	protein coding gene	Chr7:101512922-101551056 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032591	protein coding gene	Chr7:104895302-104917724 (+)
A/J	MGP_AJ_G0032567	protein coding gene	Chr7:102224073-102244622 (+)
AKR/J	MGP_AKRJ_G0032503	protein coding gene	Chr7:104671503-104691998 (+)
BALB/cJ	MGP_BALBcJ_G0032578	protein coding gene	Chr7:101923381-101944179 (+)
C3H/HeJ	MGP_C3HHeJ_G0032292	protein coding gene	Chr7:105044900-105065960 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033075	protein coding gene	Chr7:108847853-108869993 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030069	protein coding gene	Chr7:104584576-104608516 (+)
CAST/EiJ	MGP_CASTEiJ_G0031618	protein coding gene	Chr7:96597858-96622385 (+)
CBA/J	MGP_CBAJ_G0032258	protein coding gene	Chr7:112612488-112639727 (+)
DBA/2J	MGP_DBA2J_G0032410	protein coding gene	Chr7:100554717-100576097 (+)
FVB/NJ	MGP_FVBNJ_G0032366	protein coding gene	Chr7:100333733-100355668 (+)
LP/J	MGP_LPJ_G0032499	protein coding gene	Chr7:106211194-106234766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032400	protein coding gene	Chr7:113948019-113968881 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033097	protein coding gene	Chr7:103941190-103962612 (+)
PWK/PhJ	MGP_PWKPhJ_G0031336	protein coding gene	Chr7:93681979-93688130 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031180	protein coding gene	Chr7:91253108-91260788 (+)
WSB/EiJ	MGP_WSBEiJ_G0031735	protein coding gene	Chr7:104627563-104649704 (+)

Human Ortholog

ANAPC15, anaphase promoting complex subunit 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANAPC15, anaphase promoting complex subunit 15
Synonyms

APC15, C11orf51, HSPC020
Links

HGNC:24531

NCBI Gene ID: 25906

neXtProt AC: NX_P60006

UniProt: P60006
Chr Location

11q13.4; chr11:72106372-72112780 (-) GRCh38

MGI Vertebrate Homology

Anapc15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANAPC15
Gene Tree

Anapc15

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

82
Chemically induced (other)

1
Gene trapped

78
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Anapc15
Incidental Mutations

APF
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

22
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase anapc15

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All Sequences

134
RefSeq

62
UniProt

8
CCDS

CCDS21518.1, CCDS80760.1, CCDS80762.1

Ensembl

ENSMUSG00000030649 (Evidence)
NCBI Gene

75430

			Length	Strain/Species	Flank
genomic	75430	NCBI Gene Model \| MGI Sequence Detail	20549	C57BL/6J	± kb
transcript	NM_027532	RefSeq \| MGI Sequence Detail	885	C57BL/6
polypeptide	P60007	UniProt \| EBI \| MGI Sequence Detail	132	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000031606 anaphase-promoting complex subunit 15

(term hierarchy)
InterPro Domains

IPR026182 Anaphase-promoting complex subunit 15

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All nucleic 13

cDNA 13

Microarray probesets 10

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MGI:1917991

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 19
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Anapc15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68277	Chr7:101530504-101530527 (+)	8 bp
Tssr68278	Chr7:101531953-101531961 (+)	1,449 bp
Tssr68279	Chr7:101534050-101534056 (+)	3,545 bp
Tssr68280	Chr7:101545579-101545638 (+)	15,101 bp
Tssr68281	Chr7:101546024-101546057 (+)	15,533 bp
Tssr68282	Chr7:101546059-101546076 (+)	15,560 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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