Dynap Gene Detail

Summary

• Symbol
  Dynap
• Name
  dynactin associated protein
• Synonyms
  2310002L13Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1922827
  NCBI Gene: 75577
• Alliance
  gene page
• Transcription Start Sites
  7 TSS
• Candidate for QTL
  1 QTL

Location &
Maps

• Sequence Map
  Chr18:70373500-70377653 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, 44.21 cM, cytoband E2
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  349 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922827	protein coding gene	Chr18:70373500-70377655 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024541	protein coding gene	Chr18:70708050-70712803 (-)
A/J	MGP_AJ_G0024508	protein coding gene	Chr18:67609325-67613480 (-)
AKR/J	MGP_AKRJ_G0024479	protein coding gene	Chr18:69578103-69582259 (-)
BALB/cJ	MGP_BALBcJ_G0024508	protein coding gene	Chr18:67758434-67762598 (-)
C3H/HeJ	MGP_C3HHeJ_G0024276	protein coding gene	Chr18:69704635-69708790 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024954	protein coding gene	Chr18:72521716-72525871 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022385	protein coding gene	Chr18:66923819-66927977 (-)
CAST/EiJ	MGP_CASTEiJ_G0023749	protein coding gene	Chr18:69828335-69833283 (-)
CBA/J	MGP_CBAJ_G0024245	protein coding gene	Chr18:74991608-74995763 (-)
DBA/2J	MGP_DBA2J_G0024375	protein coding gene	Chr18:67234496-67239028 (-)
FVB/NJ	MGP_FVBNJ_G0024341	protein coding gene	Chr18:66605939-66610094 (-)
LP/J	MGP_LPJ_G0024459	protein coding gene	Chr18:70566354-70570509 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024371	protein coding gene	Chr18:76240664-76246387 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025002	protein coding gene	Chr18:69764302-69768457 (-)
PWK/PhJ	MGP_PWKPhJ_G0023493	protein coding gene	Chr18:67595325-67599564 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023297	protein coding gene	Chr18:69910224-69914483 (-)
WSB/EiJ	MGP_WSBEiJ_G0023812	protein coding gene	Chr18:69700707-69704853 (-)

Homology

• Human Ortholog
  DYNAP, dynactin associated protein

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DYNAP, dynactin associated protein
  
• Synonyms
  C18orf26
• Links
  HGNC:26808

  NCBI Gene ID: 284254

  neXtProt AC: NX_Q8N1N2

  UniProt: Q8N1N2

  
  
• Chr Location
  18q21.2; chr18:54575621-54599493 (+)  GRCh38

---

• MGI Vertebrate Homology
  Dynap stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: DYNAP
• Gene Tree
  Dynap
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  4
• Targeted
  4
• Incidental Mutations
  APF
• Find Mice (IMSR)
  18 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  10
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS50316.1

• Ensembl
  ENSMUSG00000024512 (Evidence)
• NCBI Gene
  75577

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000024512	Ensembl Gene Model | MGI Sequence Detail	4154	C57BL/6J
transcript	ENSMUST00000025390	Ensembl | MGI Sequence Detail	1225	Not Applicable
polypeptide	ENSMUSP00000025390	Ensembl | MGI Sequence Detail	161	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 2

  cDNA 2

  
  

  Microarray probesets 4

References

• Summaries
  All 23

  Gene Ontology 2

  Phenotypes 3
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Dynap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153834	Chr18:70377756-70377767 (-)	-109 bp
Tssr153833	Chr18:70377661-70377672 (-)	-14 bp
Tssr153832	Chr18:70377631-70377636 (-)	19 bp
Tssr153831	Chr18:70377551-70377567 (-)	94 bp
Tssr153830	Chr18:70377489-70377499 (-)	159 bp
Tssr153829	Chr18:70377460-70377466 (-)	190 bp
Tssr153828	Chr18:70377444-70377449 (-)	206 bp

Dynap is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Par2	Chr18, 44.19 cM	Chr18:70362333-76707156	J:98656	In a previous study, the Par2 (pulmonary adenoma resistance 2) locus was localized to a 2.4 Mb interval between D18Mit103 (44 cM) and D18Mit188 (47 cM). The current study examines possible candidate genes found within the Par2 critical region. These genes are 2310002L13Rik, Stard6 (44 cM), Poli, Mbd2 (44 cM), and Dcc (45 cM). Poli shows the strongest evidence as a Par2 candidate gene. Sequence analysis revealed 25 nucleotide polymorphisms between lung tumor susceptible strain A/J and lung tumor resistantstrain BALB/cJ resulting in 10 amino acid differences. Two different Poli alternative transcripts (exon 4a and exon 2d) were also observed in lung mRNA of A/J and BALB/cJ animals. The exon 4a isoform encodes a truncated protein due to a premature stop codon, and the exon 2d isoform results in the splicing out of exon 2 without disruption of the reading frame. Resistant strain BALB/cJ produces decreased levels of functional Poli protein due to increased expression of the exon 4a isoform. The Poli protein also displays functional differences and substrate preference between A/J and BALB/cJ strains.

*cM position of peak correlated region/marker