Zbtb4 MGI Mouse Gene Detail - MGI:1922830 - zinc finger and BTB domain containing 4

Symbol

Zbtb4
Name

zinc finger and BTB domain containing 4
Synonyms

2310026P19Rik, 9230111I22Rik

Feature Type

protein coding gene
IDs

MGI:1922830
NCBI Gene: 75580
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:69656738-69674849 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.87 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

287 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922830	protein coding gene	Chr11:69656738-69674852 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018553	protein coding gene	Chr11:70242737-70262002 (+)
A/J	MGP_AJ_G0018521	protein coding gene	Chr11:67586959-67604997 (+)
AKR/J	MGP_AKRJ_G0018490	protein coding gene	Chr11:69604816-69622824 (+)
BALB/cJ	MGP_BALBcJ_G0018493	protein coding gene	Chr11:67907393-67930200 (+)
C3H/HeJ	MGP_C3HHeJ_G0018306	protein coding gene	Chr11:69635802-69654884 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018944	protein coding gene	Chr11:72367773-72385824 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016589	protein coding gene	Chr11:64507977-64525912 (+)
CAST/EiJ	MGP_CASTEiJ_G0017861	protein coding gene	Chr11:69874706-69893787 (+)
CBA/J	MGP_CBAJ_G0018279	protein coding gene	Chr11:75603030-75624573 (+)
DBA/2J	MGP_DBA2J_G0018388	protein coding gene	Chr11:67168391-67186877 (+)
FVB/NJ	MGP_FVBNJ_G0018378	protein coding gene	Chr11:66809957-66828850 (+)
LP/J	MGP_LPJ_G0018458	protein coding gene	Chr11:70806505-70824553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018401	protein coding gene	Chr11:76215772-76234409 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018986	protein coding gene	Chr11:69868736-69886788 (+)
PWK/PhJ	MGP_PWKPhJ_G0017635	protein coding gene	Chr11:67819543-67837774 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017425	protein coding gene	Chr11:69688001-69707711 (+)
WSB/EiJ	MGP_WSBEiJ_G0017915	protein coding gene	Chr11:69535583-69553641 (+)

Human Ortholog

ZBTB4, zinc finger and BTB domain containing 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB4, zinc finger and BTB domain containing 4
Synonyms

KAISO-L1, ZNF903
Links

HGNC:23847

NCBI Gene ID: 57659

neXtProt AC: NX_Q9P1Z0

UniProt: Q9P1Z0
Chr Location

17p13.1; chr17:7459366-7484263 (-) GRCh38

MGI Vertebrate Homology

Zbtb4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZBTB4
Gene Tree

Zbtb4

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Targeted

6
Genomic Mutations

2 involving Zbtb4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

59
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN zbtb4

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All Sequences

70
RefSeq

16
UniProt

7
CCDS

CCDS36197.2

Ensembl

ENSMUSG00000018750 (Evidence)
NCBI Gene

75580

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018750	Ensembl Gene Model \| MGI Sequence Detail	18112	C57BL/6J	± kb
transcript	ENSMUST00000108640	Ensembl \| MGI Sequence Detail	4067	Not Applicable
polypeptide	ENSMUSP00000104280	Ensembl \| MGI Sequence Detail	982	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017580 zinc finger and BTB domain-containing protein 4

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR050457 Zinc finger and BTB domain-containing

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:1925007

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zbtb4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102529	Chr11:69656725-69656751 (+)	0 bp
Tssr102530	Chr11:69656796-69656853 (+)	87 bp
Tssr102531	Chr11:69657321-69657385 (+)	615 bp
Tssr102532	Chr11:69666908-69666936 (+)	10,184 bp
Tssr102533	Chr11:69668425-69668438 (+)	11,694 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24