Wnk2 MGI Mouse Gene Detail - MGI:1922857 - WNK lysine deficient protein kinase 2

Symbol

Wnk2
Name

WNK lysine deficient protein kinase 2
Synonyms

1810073P09Rik, ESTM15, mKIAA1760, X83337

Feature Type

protein coding gene
IDs

MGI:1922857
NCBI Gene: 75607
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:49189779-49301490 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.07 cM, cytoband B1
Mapping Data

4 experiments

SNPs within 2kb

2228 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922857	protein coding gene	Chr13:49189778-49302110 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020529	protein coding gene	Chr13:47995696-48110669 (-)
A/J	MGP_AJ_G0020483	protein coding gene	Chr13:46286451-46398296 (-)
AKR/J	MGP_AKRJ_G0020460	protein coding gene	Chr13:47595103-47707837 (-)
BALB/cJ	MGP_BALBcJ_G0020479	protein coding gene	Chr13:46504251-46614646 (-)
C3H/HeJ	MGP_C3HHeJ_G0020278	protein coding gene	Chr13:47418644-47531441 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020912	protein coding gene	Chr13:49438997-49558564 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018497	protein coding gene	Chr13:44270777-44378177 (-)
CAST/EiJ	MGP_CASTEiJ_G0019793	protein coding gene	Chr13:47423101-47537305 (-)
CBA/J	MGP_CBAJ_G0020239	protein coding gene	Chr13:51493070-51608936 (-)
DBA/2J	MGP_DBA2J_G0020361	protein coding gene	Chr13:45815354-45925806 (-)
FVB/NJ	MGP_FVBNJ_G0020340	protein coding gene	Chr13:45329204-45442313 (-)
LP/J	MGP_LPJ_G0020436	protein coding gene	Chr13:48215540-48329141 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020369	protein coding gene	Chr13:51211291-51321486 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020955	protein coding gene	Chr13:47293791-47406278 (-)
PWK/PhJ	MGP_PWKPhJ_G0019549	protein coding gene	Chr13:45989225-46104475 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019377	protein coding gene	Chr13:45981503-46113532 (-)
WSB/EiJ	MGP_WSBEiJ_G0019855	protein coding gene	Chr13:47609997-47722187 (-)

Human Ortholog

WNK2, WNK lysine deficient protein kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNK2, WNK lysine deficient protein kinase 2
Synonyms

NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43
Links

HGNC:14542

NCBI Gene ID: 65268

neXtProt AC: NX_Q9Y3S1

UniProt: Q9Y3S1
Chr Location

9q22.31; chr9:93184122-93320572 (+) GRCh38

MGI Vertebrate Homology

Wnk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WNK2
Gene Tree

Wnk2

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Targeted

3
Genomic Mutations

1 involving Wnk2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available

less

All GO Annotations

42
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

42
cDNA Data

71
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

135
RefSeq

68
UniProt

12
CCDS

CCDS70454.1, CCDS70455.1

Ensembl

ENSMUSG00000037989 (Evidence)
NCBI Gene

75607

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037989	Ensembl Gene Model \| MGI Sequence Detail	111712	C57BL/6J	± kb
transcript	ENSMUST00000091623	Ensembl \| MGI Sequence Detail	6897	Not Applicable
polypeptide	ENSMUSP00000089212	Ensembl \| MGI Sequence Detail	2213	Not Applicable

less

UniProt

12 Sequences
Protein Ontology

PR:000017432 serine/threonine-protein kinase WNK2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

IPR050588 With No Lysine (K) Ser/Thr Protein Kinase
GlyGen

Q3UH66 4 sites, 1 O-linked glycan (4 sites)

less

All nucleic 71

cDNA 71

Microarray probesets 4

less

MGD-MRK-28128, MGI:104834, MGI:2145415

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wnk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122438	Chr13:49301407-49301513 (-)	30 bp
Tssr122437	Chr13:49301142-49301160 (-)	339 bp
Tssr122436	Chr13:49281345-49281359 (-)	20,138 bp
Tssr122435	Chr13:49215915-49215919 (-)	85,573 bp
Tssr122434	Chr13:49197394-49197403 (-)	104,091 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24