Pabpc1l MGI Mouse Gene Detail - MGI:1922908 - poly(A) binding protein, cytoplasmic 1-like

Symbol

Pabpc1l
Name

poly(A) binding protein, cytoplasmic 1-like
Synonyms

1810053B01Rik, ePAB

Feature Type

protein coding gene
IDs

MGI:1922908
NCBI Gene: 381404
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:163867370-163892458 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 84.60 cM
Mapping Data

1 experiment

SNPs within 2kb

784 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922908	protein coding gene	Chr2:163866685-163892458 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026834	protein coding gene	Chr2:169395530-169429657 (+)
A/J	MGP_AJ_G0026800	protein coding gene	Chr2:162547738-162575318 (+)
AKR/J	MGP_AKRJ_G0026771	protein coding gene	Chr2:167365567-167391025 (+)
BALB/cJ	MGP_BALBcJ_G0026809	protein coding gene	Chr2:162889885-162915259 (+)
C3H/HeJ	MGP_C3HHeJ_G0026551	protein coding gene	Chr2:167713045-167741172 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027257	protein coding gene	Chr2:174332996-174372137 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024627	protein coding gene	Chr2:155852156-155878593 (+)
CAST/EiJ	MGP_CASTEiJ_G0026012	protein coding gene	Chr2:168127464-168154693 (+)
CBA/J	MGP_CBAJ_G0026528	protein coding gene	Chr2:180611321-180644698 (+)
DBA/2J	MGP_DBA2J_G0026666	protein coding gene	Chr2:161717641-161743415 (+)
FVB/NJ	MGP_FVBNJ_G0026632	protein coding gene	Chr2:160093925-160121627 (+)
LP/J	MGP_LPJ_G0026769	protein coding gene	Chr2:169506638-169537308 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026654	protein coding gene	Chr2:184279059-184311018 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027313	protein coding gene	Chr2:167258334-167292922 (+)
PWK/PhJ	MGP_PWKPhJ_G0025746	protein coding gene	Chr2:161289209-161316462 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025549	protein coding gene	Chr2:166139781-166170223 (+)
WSB/EiJ	MGP_WSBEiJ_G0026082	protein coding gene	Chr2:168123458-168151539 (+)

Human Ortholog

PABPC1L, poly(A) binding protein cytoplasmic 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PABPC1L, poly(A) binding protein cytoplasmic 1 like
Synonyms

C20orf119, dJ1069P2.3, EPAB, PABPC1L1
Links

HGNC:15797

NCBI Gene ID: 80336

UniProt: Q4VXU2
Chr Location

chr20:44910060-44959035 (+) GRCh38

MGI Vertebrate Homology

Pabpc1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PABPC1L
Gene Tree

Pabpc1l

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

7
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired oocyte maturation and female infertility.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

29
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pabpc1l

ZFIN pabpc1l

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS50792.1

Ensembl

ENSMUSG00000054582 (Evidence)
NCBI Gene

381404

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054582	Ensembl Gene Model \| MGI Sequence Detail	25089	C57BL/6J	± kb
transcript	ENSMUST00000067715	Ensembl \| MGI Sequence Detail	2354	Not Applicable
polypeptide	ENSMUSP00000096701	Ensembl \| MGI Sequence Detail	607	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR036053 PABC (PABP) domain

IPR034364 PABP, RNA recognition motif 1

IPR045305 PABP, RNA recognition motif 2

IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote
GlyGen

A2A5N3 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 12

Primer pair 3

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pabpc1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21508	Chr2:163878902-163878916 (+)	11,539 bp
Tssr21509	Chr2:163884288-163884295 (+)	16,922 bp
Tssr21510	Chr2:163889265-163889321 (+)	21,923 bp
Tssr21511	Chr2:163889549-163889564 (+)	22,187 bp
Tssr21512	Chr2:163889587-163889596 (+)	22,222 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24