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Wdr54 Gene Detail
Summary
  • Symbol
    Wdr54
  • Name
    WD repeat domain 54
  • Synonyms
    1700030E05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922909
    NCBI Gene: 75659
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83129691-83133383 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922909
 protein coding gene Chr6:83126342-83133383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030924
 protein coding gene Chr6:84156141-84163146 (-)
A/J MGP_AJ_G0030893
 protein coding gene Chr6:80941678-80948701 (-)
AKR/J MGP_AKRJ_G0030821
 protein coding gene Chr6:83276365-83283356 (-)
BALB/cJ MGP_BALBcJ_G0030903
 protein coding gene Chr6:80961959-80968956 (-)
C3H/HeJ MGP_C3HHeJ_G0030807
 protein coding gene Chr6:101103082-101110105 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031363
 protein coding gene Chr6:86442523-86449532 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028549
 protein coding gene Chr6:79300229-79307125 (-)
CAST/EiJ MGP_CASTEiJ_G0030012
 protein coding gene Chr6:83279285-83286256 (-)
CBA/J MGP_CBAJ_G0030590
 protein coding gene Chr6:89857045-89864054 (-)
DBA/2J MGP_DBA2J_G0030743
 protein coding gene Chr6:80260757-80267778 (-)
FVB/NJ MGP_FVBNJ_G0030696
 protein coding gene Chr6:79468305-79475292 (-)
LP/J MGP_LPJ_G0030822
 protein coding gene Chr6:84149587-84156592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030732
 protein coding gene Chr6:94170392-94177385 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031387
 protein coding gene Chr6:83090737-83097759 (-)
PWK/PhJ MGP_PWKPhJ_G0029727
 protein coding gene Chr6:79154367-79161737 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029555
 protein coding gene Chr6:81933390-81940275 (-)
WSB/EiJ MGP_WSBEiJ_G0030093
 protein coding gene Chr6:83526136-83533145 (-)



Homology
more
  • Human Ortholog
    WDR54, WD repeat domain 54
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR54, WD repeat domain 54
  • Links
    NCBI Gene ID: 84058
    neXtProt AC: NX_Q9H977
    UniProt: Q9H977

  • Chr Location
    2p13.1; chr2:74421678-74425755 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75659 NCBI Gene Model | MGI Sequence Detail 3693 C57BL/6J ±  kb
transcript NM_001362120 RefSeq | MGI Sequence Detail 1302 C57BL/6  
polypeptide Q9R0D8 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029862 WD repeat-containing protein 54
    (term hierarchy)
  • InterPro Domains
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR049546 WD repeat-containing protein 54-like beta-propeller
    IPR050630 WD repeat Echinoderm Microtubule-associated Protein-like
  • GlyGen
    Q9R0D8 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:50420 Weber JS, et al., High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6. Genomics. 1998 Nov 15;54(1):107-15
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory