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Cldn22 Gene Detail
Summary
  • Symbol
    Cldn22
  • Name
    claudin 22
  • Synonyms
    2210404A22Rik, 5330431C14Rik, 9530051B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922927
    NCBI Gene: 75677
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:48277517-48278511 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.91 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922927
 protein coding gene Chr8:48277501-48278511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033603
 protein coding gene Chr8:47029389-47031742 (+)
A/J MGP_AJ_G0033585
 protein coding gene Chr8:45180542-45183358 (+)
AKR/J MGP_AKRJ_G0033510
 protein coding gene Chr8:46494029-46496136 (+)
BALB/cJ MGP_BALBcJ_G0033582
 protein coding gene Chr8:45361025-45362018 (+)
C3H/HeJ MGP_C3HHeJ_G0033291
 protein coding gene Chr8:47065711-47066624 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034098
 protein coding gene Chr8:48825405-48826398 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031046
 protein coding gene Chr8:41416114-41416995 (+)
CAST/EiJ MGP_CASTEiJ_G0032617
 protein coding gene Chr8:46528791-46530396 (+)
CBA/J MGP_CBAJ_G0033270
 protein coding gene Chr8:50738404-50743147 (+)
DBA/2J MGP_DBA2J_G0033423
 protein coding gene Chr8:44984483-44987708 (+)
FVB/NJ MGP_FVBNJ_G0033364
 protein coding gene Chr8:44451968-44453009 (+)
LP/J MGP_LPJ_G0033511
 protein coding gene Chr8:47014631-47019103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033408
 protein coding gene Chr8:50775407-50777266 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034116
 protein coding gene Chr8:46693541-46694534 (+)
PWK/PhJ MGP_PWKPhJ_G0032325
 protein coding gene Chr8:44516689-44519545 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032161
 protein coding gene Chr8:45855260-45856476 (+)
WSB/EiJ MGP_WSBEiJ_G0032733
 protein coding gene Chr8:46940257-46944271 (+)



Homology
more
  • Human Ortholog
    CLDN22, claudin 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN22, claudin 22
  • Synonyms
    CLDN21
  • Links
    NCBI Gene ID: 53842
    neXtProt AC: NX_Q8N7P3
    UniProt: Q8N7P3

  • Chr Location
    4q35.1; chr4:183318100-183320276 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    7
  • cDNA Data
    2
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038064 Ensembl Gene Model | MGI Sequence Detail 995 C57BL/6J ±  kb
transcript ENSMUST00000038693 Ensembl | MGI Sequence Detail 995 Not Applicable  
polypeptide ENSMUSP00000041676 Ensembl | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924389, MGI:1925923
References
more
  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:313345 Higashi AY, et al., Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Sci Rep. 2021 Nov 4;11(1):21642
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory