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Shld2 Gene Detail
Summary
  • Symbol
    Shld2
  • Name
    shieldin complex subunit 2
  • Synonyms
    3110001K24Rik, Fam35a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922948
    NCBI Gene: 75698
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33958990-34032450 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2032 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922948
 protein coding gene Chr14:33958905-34032528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021170
 protein coding gene Chr14:27584035-27628008 (-)
A/J MGP_AJ_G0021118
 protein coding gene Chr14:26512241-26554859 (-)
AKR/J MGP_AKRJ_G0021095
 protein coding gene Chr14:27691111-27770515 (-)
BALB/cJ MGP_BALBcJ_G0021122
 protein coding gene Chr14:26697493-26772256 (-)
C3H/HeJ MGP_C3HHeJ_G0020905
 protein coding gene Chr14:27608119-27688371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021554
 protein coding gene Chr14:28640207-28717234 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019116
 protein coding gene Chr14:26547817-26584569 (-)
CAST/EiJ MGP_CASTEiJ_G0020430
 protein coding gene Chr14:27425089-27471633 (-)
CBA/J MGP_CBAJ_G0020872
 protein coding gene Chr14:29669817-29761302 (-)
DBA/2J MGP_DBA2J_G0020994
 protein coding gene Chr14:26552235-26593599 (-)
FVB/NJ MGP_FVBNJ_G0020978
 protein coding gene Chr14:26512161-26548004 (-)
LP/J MGP_LPJ_G0021063
 protein coding gene Chr14:27920915-27955314 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021004
 protein coding gene Chr14:28820403-28862719 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021587
 protein coding gene Chr14:27525907-27569560 (-)
PWK/PhJ MGP_PWKPhJ_G0020178
 protein coding gene Chr14:26040556-26079404 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020002
 protein coding gene Chr14:27132304-27173090 (-)
WSB/EiJ MGP_WSBEiJ_G0020485
 protein coding gene Chr14:27579392-27625645 (-)



Homology
more
  • Human Ortholog
    SHLD2, shieldin complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHLD2, shieldin complex subunit 2
  • Synonyms
    bA163M19.1, FAM35A, FAM35A1, RINN2
  • Links
    NCBI Gene ID: 54537
    neXtProt AC: NX_Q86V20
    UniProt: Q86V20

  • Chr Location
    10q23.2; chr10:87094161-87191465 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    18
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041471 Ensembl Gene Model | MGI Sequence Detail 73461 C57BL/6J ±  kb
transcript ENSMUST00000111917 Ensembl | MGI Sequence Detail 3317 Not Applicable  
polypeptide ENSMUSP00000107548 Ensembl | MGI Sequence Detail 891 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000029472 shieldin complex subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR029715 Shieldin complex subunit 2
    IPR031589 Shieldin complex subunit 2, C-terminal domain
    IPR049507 Shieldin complex subunit 2, first OB fold domain
  • GlyGen
    Q3UEN2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGI:6156419
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:261998 Gupta R, et al., DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell. 2018 May 3;173(4):972-988.e23
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory