Mff MGI Mouse Gene Detail - MGI:1922984 - mitochondrial fission factor

Symbol

Mff
Name

mitochondrial fission factor
Synonyms

5230400G24Rik

Feature Type

protein coding gene
IDs

MGI:1922984
NCBI Gene: 75734
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:82702611-82730115 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 42.45 cM
Mapping Data

2 experiments

SNPs within 2kb

694 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922984	protein coding gene	Chr1:82702599-82730115 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016218	protein coding gene	Chr1:83645968-83673497 (+)
A/J	MGP_AJ_G0016201	protein coding gene	Chr1:80677489-80705075 (+)
AKR/J	MGP_AKRJ_G0016158	protein coding gene	Chr1:82876266-82906291 (+)
BALB/cJ	MGP_BALBcJ_G0016156	protein coding gene	Chr1:80821250-80848755 (+)
C3H/HeJ	MGP_C3HHeJ_G0015986	protein coding gene	Chr1:83256963-83288094 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016609	protein coding gene	Chr1:86872469-86899970 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014329	protein coding gene	Chr1:75899945-75927569 (+)
CAST/EiJ	MGP_CASTEiJ_G0015572	protein coding gene	Chr1:82677751-82705271 (+)
CBA/J	MGP_CBAJ_G0015960	protein coding gene	Chr1:89659957-89691893 (+)
DBA/2J	MGP_DBA2J_G0016061	protein coding gene	Chr1:79965227-79994756 (+)
FVB/NJ	MGP_FVBNJ_G0016064	protein coding gene	Chr1:79061224-79089136 (+)
LP/J	MGP_LPJ_G0016134	protein coding gene	Chr1:84761501-84789616 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016084	protein coding gene	Chr1:93055657-93083160 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016656	protein coding gene	Chr1:83041620-83071083 (+)
PWK/PhJ	MGP_PWKPhJ_G0015357	protein coding gene	Chr1:79406769-79435535 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015135	protein coding gene	Chr1:82240036-82267553 (+)
WSB/EiJ	MGP_WSBEiJ_G0015632	protein coding gene	Chr1:82842926-82870969 (+)

Human Ortholog

MFF, mitochondrial fission factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MFF, mitochondrial fission factor
Synonyms

C2orf33, EMPF2, GL004
Links

HGNC:24858

NCBI Gene ID: 56947

neXtProt AC: NX_Q9GZY8

UniProt: Q9GZY8
Chr Location

2q36.3; chr2:227325151-227357836 (+) GRCh38

MGI Vertebrate Homology

Mff stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MFF
Gene Tree

Mff

Diseases

1 with human MFF associations

				Human Disease	Mouse Models
				brain disease IDs brain disease DOID:936 DOID:8510 ICD10CM:G93.40 ICD10CM:G93.9 ICD9CM:348.3 ICD9CM:348.30 ICD9CM:348.9 MESH:D001927 NCI:C26920 NCI:C96413 UMLS_CUI:C0006111 UMLS_CUI:C0085584

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Mff
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available

Homozygous knockout reduces mitochondrial hyperfusion-induced apoptotic cell death of cardiac microcirculation endothelial cells after ischemia/reperfusion injury. Males exhibit sperm mitochondrial abnormalities associated with reduced respiratory chain complex IV activity, motility, and fertility.

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All GO Annotations

44
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mff

ZFIN mffa, mffb

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All Sequences

171
RefSeq

70
UniProt

9
CCDS

CCDS15098.1, CCDS78630.1, CCDS78631.1, CCDS78632.1

Ensembl

ENSMUSG00000026150 (Evidence)
NCBI Gene

75734

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026150	Ensembl Gene Model \| MGI Sequence Detail	27505	C57BL/6J	± kb
transcript	ENSMUST00000162003	Ensembl \| MGI Sequence Detail	2087	Not Applicable
polypeptide	ENSMUSP00000124334	Ensembl \| MGI Sequence Detail	316	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010366 mitochondrial fission factor

(term hierarchy)
InterPro Domains

IPR039433 Mff-like domain

IPR008518 Mff/Tango-11
GlyGen

Q6PCP5 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 9

Genomic 1

cDNA 8

Microarray probesets 3

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MGI:2138195

Summaries

All 50

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Mff:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7624	Chr1:82702602-82702616 (+)	-2 bp
Tssr7625	Chr1:82702630-82702664 (+)	36 bp
Tssr7626	Chr1:82702685-82702689 (+)	76 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24