Rab11fip1 MGI Mouse Gene Detail - MGI:1923017 - RAB11 family interacting protein 1 (class I)

Symbol

Rab11fip1
Name

RAB11 family interacting protein 1 (class I)
Synonyms

2010200K21Rik, 4833414G05Rik

Feature Type

protein coding gene
IDs

MGI:1923017
NCBI Gene: 75767
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr8:27628801-27664674 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 15.91 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

1215 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923017	protein coding gene	Chr8:27628801-27664707 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033503	protein coding gene	Chr8:25326363-25363158 (-)
A/J	MGP_AJ_G0033483	protein coding gene	Chr8:24358268-24394954 (-)
AKR/J	MGP_AKRJ_G0033408	protein coding gene	Chr8:25162072-25207899 (-)
BALB/cJ	MGP_BALBcJ_G0033479	protein coding gene	Chr8:24517313-24555476 (-)
C3H/HeJ	MGP_C3HHeJ_G0033193	protein coding gene	Chr8:25385530-25421479 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033995	protein coding gene	Chr8:26306352-26342824 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030945	protein coding gene	Chr8:21608795-21644616 (-)
CAST/EiJ	MGP_CASTEiJ_G0032519	protein coding gene	Chr8:24870504-24911987 (-)
CBA/J	MGP_CBAJ_G0033168	protein coding gene	Chr8:27343884-27388767 (-)
DBA/2J	MGP_DBA2J_G0033323	protein coding gene	Chr8:24324694-24361206 (-)
FVB/NJ	MGP_FVBNJ_G0033267	protein coding gene	Chr8:24138146-24174792 (-)
LP/J	MGP_LPJ_G0033412	protein coding gene	Chr8:25282722-25321852 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033310	protein coding gene	Chr8:26785341-26827607 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034014	protein coding gene	Chr8:25147549-25186743 (-)
PWK/PhJ	MGP_PWKPhJ_G0032230	protein coding gene	Chr8:23989277-24025509 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032064	protein coding gene	Chr8:24531389-24573110 (-)
WSB/EiJ	MGP_WSBEiJ_G0032635	protein coding gene	Chr8:25331133-25375240 (-)

Human Ortholog

RAB11FIP1, RAB11 family interacting protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB11FIP1, RAB11 family interacting protein 1
Synonyms

NOEL1A, rab11-FIP1, RCP
Links

HGNC:30265

NCBI Gene ID: 80223

neXtProt AC: NX_Q6WKZ4

UniProt: Q6WKZ4
Chr Location

8p11.23; chr8:37858618-37899497 (-) GRCh38

MGI Vertebrate Homology

Rab11fip1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RAB11FIP1
Gene Tree

Rab11fip1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available

Homozygous knockout results in reduced metastatic potential of pancreatic adenocarcinoma (PDAC) tumor cells in KPC (PDAC model) mice.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab11fip1

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All Sequences

62
RefSeq

10
UniProt

4
CCDS

CCDS40311.1, CCDS52534.1

Ensembl

ENSMUSG00000031488 (Evidence)
NCBI Gene

75767

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031488	Ensembl Gene Model \| MGI Sequence Detail	35874	C57BL/6J	± kb
transcript	ENSMUST00000054212	Ensembl \| MGI Sequence Detail	7965	Not Applicable
polypeptide	ENSMUSP00000058042	Ensembl \| MGI Sequence Detail	1166	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013581 Rab11 family-interacting protein 1

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR037245 FIP-RBD, C-terminal domain superfamily

IPR037789 Rab11-family interacting protein class I

IPR019018 Rab-binding domain FIP-RBD
GlyGen

Q9D620 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 14

cDNA 14

Microarray probesets 3

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MGI:1917512

Summaries

All 34

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab11fip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2531	Chr8:27665679-27665712 (-)	-1,022 bp
Tssr80785	Chr8:27664651-27664679 (-)	9 bp
Tssr80783	Chr8:27657114-27657118 (-)	7,558 bp
Tssr80782	Chr8:27646364-27646401 (-)	18,291 bp
Tssr80781	Chr8:27644750-27644773 (-)	19,912 bp
Tssr80780	Chr8:27632363-27632381 (-)	32,302 bp
Tssr80779	Chr8:27632342-27632353 (-)	32,326 bp
Tssr80778	Chr8:27632032-27632072 (-)	32,622 bp
Tssr80777	Chr8:27631946-27631961 (-)	32,720 bp
Tssr80776	Chr8:27631904-27631920 (-)	32,762 bp
Tssr80775	Chr8:27631733-27631748 (-)	32,933 bp
Tssr80774	Chr8:27631634-27631651 (-)	33,031 bp
Tssr80773	Chr8:27631592-27631612 (-)	33,072 bp
Tssr80772	Chr8:27631560-27631586 (-)	33,101 bp
Tssr80771	Chr8:27631548-27631559 (-)	33,120 bp
Tssr80770	Chr8:27631501-27631542 (-)	33,152 bp
Tssr80769	Chr8:27631477-27631490 (-)	33,190 bp
Tssr80768	Chr8:27630908-27630913 (-)	33,763 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24