Nln MGI Mouse Gene Detail - MGI:1923055 - neurolysin (metallopeptidase M3 family)

Symbol

Nln
Name

neurolysin (metallopeptidase M3 family)
Synonyms

4930472G13Rik

Feature Type

protein coding gene
IDs

MGI:1923055
NCBI Gene: 75805
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:104159565-104246122 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 56.16 cM
Mapping Data

3 experiments

SNPs within 2kb

2625 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923055	protein coding gene	Chr13:104159558-104246170 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020902	protein coding gene	Chr13:106112700-106198589 (-)
A/J	MGP_AJ_G0020853	protein coding gene	Chr13:101976284-102062467 (-)
AKR/J	MGP_AKRJ_G0020828	protein coding gene	Chr13:105086039-105173135 (-)
BALB/cJ	MGP_BALBcJ_G0020853	protein coding gene	Chr13:102689111-102774896 (-)
C3H/HeJ	MGP_C3HHeJ_G0020642	protein coding gene	Chr13:104820130-104907755 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021287	protein coding gene	Chr13:109304831-109394929 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018857	protein coding gene	Chr13:97594019-97680424 (-)
CAST/EiJ	MGP_CASTEiJ_G0020161	protein coding gene	Chr13:104277456-104372778 (-)
CBA/J	MGP_CBAJ_G0020604	protein coding gene	Chr13:113551736-113637442 (-)
DBA/2J	MGP_DBA2J_G0020728	protein coding gene	Chr13:101743825-101831083 (-)
FVB/NJ	MGP_FVBNJ_G0020710	protein coding gene	Chr13:100443753-100529305 (-)
LP/J	MGP_LPJ_G0020802	protein coding gene	Chr13:106130182-106222801 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020738	protein coding gene	Chr13:113715202-113803345 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021326	protein coding gene	Chr13:104554232-104642395 (-)
PWK/PhJ	MGP_PWKPhJ_G0019914	protein coding gene	Chr13:100474728-100563571 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019736	protein coding gene	Chr13:100743367-100830690 (-)
WSB/EiJ	MGP_WSBEiJ_G0020219	protein coding gene	Chr13:105021749-105110268 (-)

Human Ortholog

NLN, neurolysin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NLN, neurolysin
Synonyms

AGTBP, EP24.16, MEP, MOP
Links

HGNC:16058

NCBI Gene ID: 57486

neXtProt AC: NX_Q9BYT8

UniProt: Q9BYT8
Chr Location

5q12.3; chr5:65722205-65871725 (+) GRCh38

MGI Vertebrate Homology

Nln stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NLN
Gene Tree

Nln

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

7
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased glucose tolerance, insulin sensitivity, and gluconeogensis. Mice also show decreased body weight and run less in a low intensity regime to exhaustion.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

89
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nln

ZFIN nln

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All Sequences

65
RefSeq

15
UniProt

6
CCDS

CCDS36772.1

Ensembl

ENSMUSG00000021710 (Evidence)
NCBI Gene

75805

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021710	Ensembl Gene Model \| MGI Sequence Detail	86558	C57BL/6J	± kb
transcript	ENSMUST00000109315	Ensembl \| MGI Sequence Detail	4162	Not Applicable
polypeptide	ENSMUSP00000104938	Ensembl \| MGI Sequence Detail	704	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011260 neurolysin, mitochondrial

(term hierarchy)
EC

3.4.24.16
InterPro Domains

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR024077 Neurolysin/Thimet oligopeptidase, domain 2

IPR024080 Neurolysin/Thimet oligopeptidase, N-terminal

IPR045090 Peptidase M3A/M3B

IPR001567 Peptidase M3A/M3B catalytic domain
GlyGen

Q91YP2 1 site, 1 O-linked glycan (1 site)

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All nucleic 89

cDNA 89

Microarray probesets 4

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MGI:2145509

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 13
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139

TSS for Nln:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123915	Chr13:104246128-104246148 (-)	-16 bp
Tssr123914	Chr13:104246084-104246127 (-)	16 bp
Tssr123913	Chr13:104246021-104246082 (-)	70 bp
Tssr123912	Chr13:104174133-104174149 (-)	71,981 bp
Tssr123911	Chr13:104173069-104173111 (-)	73,032 bp
Tssr123910	Chr13:104173011-104173022 (-)	73,105 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24