Hormad2 MGI Mouse Gene Detail - MGI:1923078

Symbol

Hormad2
Name

HORMA domain containing 2
Synonyms

4930529M09Rik

Feature Type

protein coding gene
IDs

MGI:1923078
NCBI Gene: 75828
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:4295814-4391105 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.94 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

2049 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923078	protein coding gene	Chr11:4295801-4391215 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017982	protein coding gene	Chr11:1302451-1402401 (-)
A/J	MGP_AJ_G0017955	protein coding gene	Chr11:1291235-1388414 (-)
AKR/J	MGP_AKRJ_G0017919	protein coding gene	Chr11:1350676-1447048 (-)
BALB/cJ	MGP_BALBcJ_G0017923	protein coding gene	Chr11:1267491-1362364 (-)
C3H/HeJ	MGP_C3HHeJ_G0017736	protein coding gene	Chr11:1248259-1347122 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018376	protein coding gene	Chr11:1371118-1473168 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016034	protein coding gene	Chr11:1171081-1266804 (-)
CAST/EiJ	MGP_CASTEiJ_G0017298	protein coding gene	Chr11:1214703-1316136 (-)
CBA/J	MGP_CBAJ_G0017711	protein coding gene	Chr11:1617141-1722519 (-)
DBA/2J	MGP_DBA2J_G0017822	protein coding gene	Chr11:1194630-1289500 (-)
FVB/NJ	MGP_FVBNJ_G0017813	protein coding gene	Chr11:1228499-1327989 (-)
LP/J	MGP_LPJ_G0017892	protein coding gene	Chr11:1385819-1486629 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017839	protein coding gene	Chr11:1283781-1391488 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018415	protein coding gene	Chr11:1360663-1454833 (-)
PWK/PhJ	MGP_PWKPhJ_G0017079	protein coding gene	Chr11:1199385-1296648 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016875	protein coding gene	Chr11:1322284-1420969 (-)
WSB/EiJ	MGP_WSBEiJ_G0017352	protein coding gene	Chr11:1220010-1319800 (-)

Human Ortholog

HORMAD2, HORMA domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HORMAD2, HORMA domain containing 2
Synonyms

CT46.2
Links

HGNC:28383

NCBI Gene ID: 150280

neXtProt AC: NX_Q8N7B1

UniProt: Q8N7B1
Chr Location

22q12.2; chr22:30077732-30207456 (+) GRCh38

MGI Vertebrate Homology

Hormad2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HORMAD2
Gene Tree

Hormad2

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Phenotype Summary

21 phenotypes from 4 alleles in 4 genetic backgrounds
6 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

3
Gene trapped

12
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to arrest of spermatogenesis, male infertility, and abnormalities in male and female meiosis.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

13
cDNA Data

5
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

15
UniProt

3
CCDS

CCDS36096.1

Ensembl

ENSMUSG00000020419 (Evidence)
NCBI Gene

75828

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020419	Ensembl Gene Model \| MGI Sequence Detail	95292	C57BL/6J	± kb
transcript	ENSMUST00000109949	Ensembl \| MGI Sequence Detail	1343	Not Applicable
polypeptide	ENSMUSP00000105575	Ensembl \| MGI Sequence Detail	306	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031503 HORMA domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR003511 HORMA domain

IPR051294 HORMA Domain-Containing Meiotic Progression

IPR036570 HORMA domain superfamily

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All nucleic 7

cDNA 5

Primer pair 2

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:289957 Guan Y, et al., SKP1 drives the prophase I to metaphase I transition during male meiosis. Sci Adv. 2020 Mar;6(13):eaaz2129

TSS for Hormad2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106551	Chr11:4377279-4377290 (-)	13,820 bp
Tssr106550	Chr11:4296913-4296922 (-)	94,187 bp
Tssr106549	Chr11:4296898-4296908 (-)	94,202 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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