Tcam1 MGI Mouse Gene Detail - MGI:1923120 - testicular cell adhesion molecule 1

Symbol

Tcam1
Name

testicular cell adhesion molecule 1
Synonyms

4930570F09Rik

Feature Type

protein coding gene
IDs

MGI:1923120
NCBI Gene: 75870
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:106167498-106179571 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.89 cM
Mapping Data

3 experiments

SNPs within 2kb

438 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923120	protein coding gene	Chr11:106163856-106179571 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019302	protein coding gene	Chr11:109566712-109580271 (+)
A/J	MGP_AJ_G0019270	protein coding gene	Chr11:104903527-104915540 (+)
AKR/J	MGP_AKRJ_G0019239	protein coding gene	Chr11:108030898-108042970 (+)
BALB/cJ	MGP_BALBcJ_G0019244	protein coding gene	Chr11:105312269-105324340 (+)
C3H/HeJ	MGP_C3HHeJ_G0019053	protein coding gene	Chr11:108320431-108332729 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019694	protein coding gene	Chr11:112916236-112929795 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017318	protein coding gene	Chr11:102181092-102193686 (+)
CAST/EiJ	MGP_CASTEiJ_G0018606	protein coding gene	Chr11:109376410-109393133 (+)
CBA/J	MGP_CBAJ_G0019022	protein coding gene	Chr11:117616332-117628425 (+)
DBA/2J	MGP_DBA2J_G0019134	protein coding gene	Chr11:104371563-104383648 (+)
FVB/NJ	MGP_FVBNJ_G0019125	protein coding gene	Chr11:103875483-103887648 (+)
LP/J	MGP_LPJ_G0019204	protein coding gene	Chr11:110010468-110023360 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019155	protein coding gene	Chr11:116900585-116914671 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019731	protein coding gene	Chr11:108525136-108538113 (+)
PWK/PhJ	MGP_PWKPhJ_G0018371	protein coding gene	Chr11:105469144-105484294 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018162	protein coding gene	Chr11:108286053-108303884 (+)
WSB/EiJ	MGP_WSBEiJ_G0018657	protein coding gene	Chr11:108482863-108497780 (+)

Human Ortholog

TCAM1P, testicular cell adhesion molecule 1, pseudogene

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TCAM1P, testicular cell adhesion molecule 1, pseudogene
Synonyms

TCAM1
Links

HGNC:30707

NCBI Gene ID: 146771
Chr Location

17q23.3; chr17:63849292-63864379 (+) GRCh38

MGI Vertebrate Homology

Tcam1 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: TCAM1P
Gene Tree

Tcam1

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal male fertility.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

950
Tissues

37
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

10
UniProt

3
CCDS

CCDS48959.1

Ensembl

ENSMUSG00000020712 (Evidence)
NCBI Gene

75870

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020712	Ensembl Gene Model \| MGI Sequence Detail	12074	C57BL/6J	± kb
transcript	ENSMUST00000044462	Ensembl \| MGI Sequence Detail	3511	Not Applicable
polypeptide	ENSMUSP00000044757	Ensembl \| MGI Sequence Detail	548	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR048679 Intercellular adhesion molecule 1/3/5, D2 domain

IPR013768 Intercellular adhesion molecule, N-terminal

IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule

IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:2144159

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 6
Earliest

J:66483 Sakatani S, et al., Structure, expression, and conserved physical linkage of mouse testicular cell adhesion molecule-1 (TCAM-1) gene. Genome. 2000 Dec;43(6):957-62
Latest

J:254290 Kurihara M, et al., A Testis-Specific Long Non-Coding RNA, lncRNA-Tcam1, Regulates Immune-Related Genes in Mouse Male Germ Cells. Front Endocrinol (Lausanne). 2017;8:299

TSS for Tcam1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105511	Chr11:106167477-106167514 (+)	-2 bp
Tssr105512	Chr11:106167517-106167528 (+)	25 bp
Tssr105513	Chr11:106167541-106167553 (+)	49 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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