Dcp1a MGI Mouse Gene Detail - MGI:1923151

Symbol

Dcp1a
Name

decapping mRNA 1A
Synonyms

1110066A22Rik, 4930568L04Rik, D14Ertd817e, Mitc1, SMIF

Feature Type

protein coding gene
IDs

MGI:1923151
NCBI Gene: 75901
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:30201613-30249013 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.75 cM, cytoband B
Mapping Data

5 experiments

SNPs within 2kb

1355 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923151	protein coding gene	Chr14:30201492-30249020 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021103	protein coding gene	Chr14:23605739-23653215 (+)
A/J	MGP_AJ_G0021051	protein coding gene	Chr14:22726863-22774532 (+)
AKR/J	MGP_AKRJ_G0021028	protein coding gene	Chr14:23832652-23880217 (+)
BALB/cJ	MGP_BALBcJ_G0021055	protein coding gene	Chr14:22820169-22868272 (+)
C3H/HeJ	MGP_C3HHeJ_G0020838	protein coding gene	Chr14:23687960-23736140 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021487	protein coding gene	Chr14:24542434-24589892 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019050	protein coding gene	Chr14:22793075-22839163 (+)
CAST/EiJ	MGP_CASTEiJ_G0020363	protein coding gene	Chr14:23426599-23475739 (+)
CBA/J	MGP_CBAJ_G0020805	protein coding gene	Chr14:25492545-25540350 (+)
DBA/2J	MGP_DBA2J_G0020927	protein coding gene	Chr14:22759650-22807131 (+)
FVB/NJ	MGP_FVBNJ_G0020911	protein coding gene	Chr14:22716053-22764244 (+)
LP/J	MGP_LPJ_G0020996	protein coding gene	Chr14:23927065-23974548 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020937	protein coding gene	Chr14:24769337-24816903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021520	protein coding gene	Chr14:23576276-23623833 (+)
PWK/PhJ	MGP_PWKPhJ_G0020111	protein coding gene	Chr14:22189987-22239255 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019935	protein coding gene	Chr14:23166252-23221583 (+)
WSB/EiJ	MGP_WSBEiJ_G0020418	protein coding gene	Chr14:23640582-23689617 (+)

Human Ortholog

DCP1A, decapping mRNA 1A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCP1A, decapping mRNA 1A
Synonyms

HSA275986, Nbla00360, SMAD4IP1, SMIF
Links

HGNC:18714

NCBI Gene ID: 55802

neXtProt AC: NX_Q9NPI6

UniProt: Q9NPI6
Chr Location

3p21.1; chr3:53283429-53347586 (-) GRCh38

MGI Vertebrate Homology

Dcp1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCP1A
Gene Tree

Dcp1a

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

4
Gene trapped

11
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic growth retardation and die around E10.5.

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All GO Annotations

26
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

39
cDNA Data

120
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcp1a

ZFIN dcp1a

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All Sequences

73
RefSeq

8
UniProt

4
CCDS

CCDS36848.1

Ensembl

ENSMUSG00000021962 (Evidence)
NCBI Gene

75901

			Length	Strain/Species	Flank
genomic	75901	NCBI Gene Model \| MGI Sequence Detail	47401	C57BL/6J	± kb
transcript	NM_133761	RefSeq \| MGI Sequence Detail	5525	ZRU/MplStud
polypeptide	Q91YD3	UniProt \| EBI \| MGI Sequence Detail	602	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006317 mRNA-decapping enzyme 1A

(term hierarchy)
EC

3.6.1.62
InterPro Domains

IPR031953 mRNA-decapping enzyme, C-terminal

IPR010334 mRNA-decapping enzyme subunit 1

IPR011993 PH-like domain superfamily
GlyGen

Q91YD3 7 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (6 sites)

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All nucleic 122

cDNA 120

Primer pair 2

Microarray probesets 5

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MGI:1289310, MGI:1916184, MGI:2145732

Summaries

All 70

Developmental Gene Expression 20

Gene Ontology 13

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687

TSS for Dcp1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124825	Chr14:30201577-30201642 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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