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Vmp1 Gene Detail
Summary
  • Symbol
    Vmp1
  • Name
    vacuole membrane protein 1
  • Synonyms
    3110098I04Rik, 4930579A11Rik, Tango5, Tmem49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923159
    NCBI Gene: 75909
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86474691-86574662 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923159
 protein coding gene Chr11:86474684-86574662 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018892
 protein coding gene Chr11:88154240-88258056 (-)
A/J MGP_AJ_G0018859
 protein coding gene Chr11:84761868-84862485 (-)
AKR/J MGP_AKRJ_G0018829
 protein coding gene Chr11:87299496-87403209 (-)
BALB/cJ MGP_BALBcJ_G0018832
 protein coding gene Chr11:85145284-85245318 (-)
C3H/HeJ MGP_C3HHeJ_G0018646
 protein coding gene Chr11:87322070-87424962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019284
 protein coding gene Chr11:90814574-90917848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016917
 protein coding gene Chr11:81784439-81883454 (-)
CAST/EiJ MGP_CASTEiJ_G0018201
 protein coding gene Chr11:88010349-88117568 (-)
CBA/J MGP_CBAJ_G0018617
 protein coding gene Chr11:94636004-94744549 (-)
DBA/2J MGP_DBA2J_G0018725
 protein coding gene Chr11:84331085-84432593 (-)
FVB/NJ MGP_FVBNJ_G0018714
 protein coding gene Chr11:83833162-83933625 (-)
LP/J MGP_LPJ_G0018795
 protein coding gene Chr11:88640246-88745763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018741
 protein coding gene Chr11:94736526-94847692 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019324
 protein coding gene Chr11:87543322-87645989 (-)
PWK/PhJ MGP_PWKPhJ_G0017970
 protein coding gene Chr11:85125059-85228803 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017762
 protein coding gene Chr11:87097581-87200608 (-)
WSB/EiJ MGP_WSBEiJ_G0018252
 protein coding gene Chr11:87413179-87517182 (-)



Homology
more
  • Human Ortholog
    VMP1, vacuole membrane protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VMP1, vacuole membrane protein 1
  • Synonyms
    EPG3, TANGO5, TMEM49
  • Links
    NCBI Gene ID: 81671
    neXtProt AC: NX_Q96GC9
    UniProt: Q96GC9

  • Chr Location
    17q23.1; chr17:59707192-59842255 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality between E7.5 and E9.5 with reduced size at E7.5 and neutral lipid accumulation in visceral endoderm cells. Mice homozygous for a conditional allele activated in intestinal epithelia exhibit reduced body weight and neutral lipid accumulation in intestinal epithelia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018171 Ensembl Gene Model | MGI Sequence Detail 99972 C57BL/6J ±  kb
    transcript ENSMUST00000018315 Ensembl | MGI Sequence Detail 2787 Not Applicable  
    polypeptide ENSMUSP00000018315 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925760, MGI:2144264
    References
    more
    • Summaries
      All 55
      Gene Ontology 11
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357749 Liu Y, et al., VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival. J Exp Med. 2023 Jun 5;220(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory