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Treml4 Gene Detail
Summary
  • Symbol
    Treml4
  • Name
    triggering receptor expressed on myeloid cells-like 4
  • Synonyms
    5031403H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923239
    NCBI Gene: 224840
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48571323-48582388 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923239
 protein coding gene Chr17:48571229-48582635 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023866
 protein coding gene Chr17:49535218-49546817 (+)
A/J MGP_AJ_G0023826
 protein coding gene Chr17:48241943-48253006 (+)
AKR/J MGP_AKRJ_G0023794
 protein coding gene Chr17:48713597-48724659 (+)
BALB/cJ MGP_BALBcJ_G0023828
 protein coding gene Chr17:48165870-48176936 (+)
C3H/HeJ MGP_C3HHeJ_G0023591
 protein coding gene Chr17:49422596-49433658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024271
 protein coding gene Chr17:51641782-51652847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021720
 protein coding gene Chr17:45002790-45014023 (+)
CAST/EiJ MGP_CASTEiJ_G0023073
 protein coding gene Chr17:49604514-49615685 (+)
CBA/J MGP_CBAJ_G0023567
 protein coding gene Chr17:53484827-53495889 (+)
DBA/2J MGP_DBA2J_G0023696
 protein coding gene Chr17:47009728-47020790 (+)
FVB/NJ MGP_FVBNJ_G0023662
 protein coding gene Chr17:46669974-46681047 (+)
LP/J MGP_LPJ_G0023776
 protein coding gene Chr17:50242751-50253823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023690
 protein coding gene Chr17:52983848-52994917 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024317
 protein coding gene Chr17:49052414-49063484 (+)
PWK/PhJ MGP_PWKPhJ_G0022818
 protein coding gene Chr17:46438266-46449351 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022632
 protein coding gene Chr17:45950111-45961206 (+)
WSB/EiJ MGP_WSBEiJ_G0023137
 protein coding gene Chr17:49641217-49652277 (+)



Homology
more
  • Human Ortholog
    TREML4, triggering receptor expressed on myeloid cells like 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TREML4, triggering receptor expressed on myeloid cells like 4
  • Synonyms
    TLT-4, TLT4
  • Links
    NCBI Gene ID: 285852
    neXtProt AC: NX_Q6UXN2
    UniProt: Q6UXN2

  • Chr Location
    6p21.1; chr6:41228339-41238882 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Mice homozygous for a knock-out allele do not exhibit any significant alterations in the uptake and cross-presentation of dying cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051682 Ensembl Gene Model | MGI Sequence Detail 11066 C57BL/6J ±  kb
transcript ENSMUST00000154335 Ensembl | MGI Sequence Detail 838 Not Applicable  
polypeptide ENSMUSP00000118772 Ensembl | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
Other
Accession IDs
less
MGI:2147108
References
more
  • Summaries
    All 32
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:305660 Gonzalez-Cotto M, et al., TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse. Front Immunol. 2020;11:397
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory