Nabp1 MGI Mouse Gene Detail - MGI:1923258 - nucleic acid binding protein 1

Symbol

Nabp1
Name

nucleic acid binding protein 1
Synonyms

4930434H03Rik, 4930442A21Rik, 4930488J04Rik, 4933440J18Rik, 5830411E10Rik, Nbp1, Obfc2a, Ssb2

Feature Type

protein coding gene
IDs

MGI:1923258
NCBI Gene: 109019
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:51505021-51517584 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.58 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

302 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923258	protein coding gene	Chr1:51504127-51517634 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016003	protein coding gene	Chr1:50952257-50964777 (-)
A/J	MGP_AJ_G0015985	protein coding gene	Chr1:49247930-49260574 (-)
AKR/J	MGP_AKRJ_G0015941	protein coding gene	Chr1:50285211-50297735 (-)
BALB/cJ	MGP_BALBcJ_G0015942	protein coding gene	Chr1:49065262-49077814 (-)
C3H/HeJ	MGP_C3HHeJ_G0015774	protein coding gene	Chr1:50689819-50704629 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016393	protein coding gene	Chr1:53127456-53139945 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014131	protein coding gene	Chr1:42589314-42602641 (+)
CAST/EiJ	MGP_CASTEiJ_G0015355	protein coding gene	Chr1:50153087-50165649 (-)
CBA/J	MGP_CBAJ_G0015745	protein coding gene	Chr1:54538953-54551477 (-)
DBA/2J	MGP_DBA2J_G0015846	protein coding gene	Chr1:48509124-48521611 (-)
FVB/NJ	MGP_FVBNJ_G0015848	protein coding gene	Chr1:47972575-47985106 (-)
LP/J	MGP_LPJ_G0015917	protein coding gene	Chr1:51435187-51447714 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015868	protein coding gene	Chr1:57576237-57589326 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016441	protein coding gene	Chr1:50415937-50428433 (-)
PWK/PhJ	MGP_PWKPhJ_G0015141	protein coding gene	Chr1:48376439-48389046 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014921	protein coding gene	Chr1:50073722-50086304 (-)
WSB/EiJ	MGP_WSBEiJ_G0015418	protein coding gene	Chr1:50222299-50234823 (-)

Human Ortholog

NABP1, nucleic acid binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NABP1, nucleic acid binding protein 1
Synonyms

NABP1-OT1, OBFC2A, SOSS-B2, SSB2
Links

HGNC:26232

NCBI Gene ID: 64859

neXtProt AC: NX_Q96AH0

UniProt: Q96AH0
Chr Location

2q32.3; chr2:191678068-191741097 (+) GRCh38

MGI Vertebrate Homology

Nabp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NABP1
Gene Tree

Nabp1

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Nabp1
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no detectable changes in thymopoiesis, splenic development, or spermatogenesis despite a reduction in testis weight.

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

783
Tissues

53
cDNA Data

28
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nabp1a, nabp1b

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All Sequences

81
RefSeq

11
UniProt

3
CCDS

CCDS35559.1, CCDS78580.1

Ensembl

ENSMUSG00000026107 (Evidence)
NCBI Gene

109019

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026107	Ensembl Gene Model \| MGI Sequence Detail	12564	C57BL/6J	± kb
transcript	ENSMUST00000027279	Ensembl \| MGI Sequence Detail	2838	Not Applicable
polypeptide	ENSMUSP00000027279	Ensembl \| MGI Sequence Detail	198	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011583 SOSS complex subunit B2

(term hierarchy)
InterPro Domains

IPR012340 Nucleic acid-binding, OB-fold

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

IPR051231 SOSS complex subunit B

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 9

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MGI:1918489, MGI:1921210, MGI:1921237, MGI:1922042, MGI:2138363

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Nabp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11571	Chr1:51517549-51517565 (-)	27 bp
Tssr11570	Chr1:51517282-51517290 (-)	298 bp
Tssr11569	Chr1:51517070-51517082 (-)	508 bp
Tssr11568	Chr1:51516871-51516889 (-)	704 bp
Tssr11567	Chr1:51514494-51514508 (-)	3,083 bp
Tssr11566	Chr1:51513176-51513205 (-)	4,393 bp
Tssr11565	Chr1:51513102-51513137 (-)	4,464 bp
Tssr11564	Chr1:51512584-51512626 (-)	4,979 bp
Tssr11563	Chr1:51505266-51505274 (-)	12,314 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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