Ncapg2 MGI Mouse Gene Detail - MGI:1923294 - non-SMC condensin II complex, subunit G2

Symbol

Ncapg2
Name

non-SMC condensin II complex, subunit G2
Synonyms

5830426I05Rik, Luzp5, mCAP-G2, Mtb

Feature Type

protein coding gene
IDs

MGI:1923294
NCBI Gene: 76044
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:116368969-116427152 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 62.65 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

1582 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923294	protein coding gene	Chr12:116368969-116427351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020182	protein coding gene	Chr12:119270520-119329490 (+)
A/J	MGP_AJ_G0020138	protein coding gene	Chr12:114917314-114971746 (+)
AKR/J	MGP_AKRJ_G0020113	protein coding gene	Chr12:118406990-118461441 (+)
BALB/cJ	MGP_BALBcJ_G0020121	protein coding gene	Chr12:115341922-115405254 (+)
C3H/HeJ	MGP_C3HHeJ_G0019925	protein coding gene	Chr12:118667629-118735888 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020568	protein coding gene	Chr12:123042327-123106161 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018180	protein coding gene	Chr12:111329635-111384925 (+)
CAST/EiJ	MGP_CASTEiJ_G0019465	protein coding gene	Chr12:112517051-112576068 (+)
CBA/J	MGP_CBAJ_G0019892	protein coding gene	Chr12:127922130-127983957 (+)
DBA/2J	MGP_DBA2J_G0020009	protein coding gene	Chr12:114279277-114334135 (+)
FVB/NJ	MGP_FVBNJ_G0019994	protein coding gene	Chr12:112973168-113032019 (+)
LP/J	MGP_LPJ_G0020083	protein coding gene	Chr12:119311503-119372075 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020030	protein coding gene	Chr12:131230929-131297385 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020597	protein coding gene	Chr12:117570504-117628938 (+)
PWK/PhJ	MGP_PWKPhJ_G0019227	protein coding gene	Chr12:109038122-109097513 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019032	protein coding gene	Chr12:110513832-110572684 (+)
WSB/EiJ	MGP_WSBEiJ_G0019523	protein coding gene	Chr12:118525093-118583572 (+)

Human Ortholog

NCAPG2, non-SMC condensin II complex subunit G2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCAPG2, non-SMC condensin II complex subunit G2
Synonyms

3KS, CAP-G2, CAPG2, hCAP-G2, LUZP5, MTB
Links

HGNC:21904

NCBI Gene ID: 54892

neXtProt AC: NX_Q86XI2

UniProt: Q86XI2
Chr Location

7q36.3; chr7:158631169-158704804 (-) GRCh38

MGI Vertebrate Homology

Ncapg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCAPG2
Gene Tree

Ncapg2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

13
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

29
cDNA Data

94
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncapg2

ZFIN ncapg2

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All Sequences

69
RefSeq

18
UniProt

6
CCDS

CCDS26212.1

Ensembl

ENSMUSG00000042029 (Evidence)
NCBI Gene

76044

			Length	Strain/Species	Flank
genomic	76044	NCBI Gene Model \| MGI Sequence Detail	58184	C57BL/6J	± kb
transcript	NM_133762	RefSeq \| MGI Sequence Detail	6571	C57BL/6
polypeptide	Q6DFV1	UniProt \| EBI \| MGI Sequence Detail	1138	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011023 condensin-2 complex subunit G2

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR024741 Condensin-2 complex subunit G2
GlyGen

Q6DFV1 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 95

cDNA 94

Primer pair 1

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:222181 Nishide K, et al., Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet. 2014 Dec;10(12):e1004847

TSS for Ncapg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115522	Chr12:116368961-116368983 (+)	3 bp
Tssr115523	Chr12:116369017-116369086 (+)	83 bp
Tssr115524	Chr12:116406569-116406596 (+)	37,614 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24