About   Help   FAQ
Jakmip1 Gene Detail
Summary
  • Symbol
    Jakmip1
  • Name
    janus kinase and microtubule interacting protein 1
  • Synonyms
    5830437M04Rik, C330021K24Rik, Gababrbp, Marlin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923321
    NCBI Gene: 76071
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:37185679-37307951 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923321
 protein coding gene Chr5:37182424-37307958 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029498
 protein coding gene Chr5:35366099-35492181 (+)
A/J MGP_AJ_G0029464
 protein coding gene Chr5:34211440-34343820 (+)
AKR/J MGP_AKRJ_G0029414
 protein coding gene Chr5:35504107-35633275 (+)
BALB/cJ MGP_BALBcJ_G0029475
 protein coding gene Chr5:34709683-34833033 (+)
C3H/HeJ MGP_C3HHeJ_G0029198
 protein coding gene Chr5:35501590-35627088 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029929
 protein coding gene Chr5:37284282-37413722 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027167
 protein coding gene Chr5:31934135-32055605 (+)
CAST/EiJ MGP_CASTEiJ_G0028606
 protein coding gene Chr5:34650660-34779357 (+)
CBA/J MGP_CBAJ_G0029165
 protein coding gene Chr5:38201878-38342383 (+)
DBA/2J MGP_DBA2J_G0029312
 protein coding gene Chr5:34336463-34460311 (+)
FVB/NJ MGP_FVBNJ_G0029271
 protein coding gene Chr5:33818731-33940218 (+)
LP/J MGP_LPJ_G0029398
 protein coding gene Chr5:35826299-35952912 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029301
 protein coding gene Chr5:38930556-39061811 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029962
 protein coding gene Chr5:34992983-35118600 (+)
PWK/PhJ MGP_PWKPhJ_G0028330
 protein coding gene Chr5:33520474-33643973 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028163
 protein coding gene Chr5:34461050-34589773 (+)
WSB/EiJ MGP_WSBEiJ_G0028687
 protein coding gene Chr5:35078163-35207722 (+)



Homology
more
  • Human Ortholog
    JAKMIP1, janus kinase and microtubule interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JAKMIP1, janus kinase and microtubule interacting protein 1
  • Synonyms
    Gababrbp, JAMIP1, MARLIN1
  • Links
    NCBI Gene ID: 152789
    neXtProt AC: NX_Q96N16
    UniProt: Q96N16

  • Chr Location
    4p16.1; chr4:6026199-6200591 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Jakmip1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in social deficits, stereotyped activity, abnormal postnatal vocalizations, reduced anxiety/increased impulsivity and glutamatergic NMDAR signaling deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    19
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063646 Ensembl Gene Model | MGI Sequence Detail 122273 C57BL/6J ±  kb
    transcript ENSMUST00000121010 Ensembl | MGI Sequence Detail 2496 Not Applicable  
    polypeptide ENSMUSP00000113624 Ensembl | MGI Sequence Detail 831 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009199 Janus kinase and microtubule-interacting protein 1
      (term hierarchy)
    • InterPro Domains
      IPR024836 Janus kinase and microtubule-interacting protein
      IPR031994 Janus kinase and microtubule-interacting protein, C-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925951
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory