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Gbp8 Gene Detail
Summary
  • Symbol
    Gbp8
  • Name
    guanylate-binding protein 8
  • Synonyms
    5830443L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923324
    NCBI Gene: 76074
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105160379-105201475 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    850 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923324
 protein coding gene Chr5:105160379-105287406 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029820
 protein coding gene Chr5:106783399-107031166 (-)
A/J MGP_AJ_G0029784
 protein coding gene Chr5:102625493-102738432 (-)
AKR/J MGP_AKRJ_G0029732
 protein coding gene Chr5:106110722-106507428 (-)
BALB/cJ MGP_BALBcJ_G0029798
 protein coding gene Chr5:103856907-104053191 (-)
C3H/HeJ MGP_C3HHeJ_G0029518
 protein coding gene Chr5:106505337-106630063 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030250
 protein coding gene Chr5:111176115-111344951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027484
 protein coding gene Chr5:97923591-97948839 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0029489
 protein coding gene Chr5:115051868-115177731 (-)
DBA/2J MGP_DBA2J_G0029633
 protein coding gene Chr5:102937302-103072176 (-)
FVB/NJ MGP_FVBNJ_G0029590
 protein coding gene Chr5:101682424-102064084 (-)
LP/J MGP_LPJ_G0029722
 protein coding gene Chr5:107489911-107551156 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0030284
 protein coding gene Chr5:105590628-105640786 (-)
PWK/PhJ MGP_PWKPhJ_G0028645
 protein coding gene Chr5:101372389-101401034 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028485
 protein coding gene Chr5:103282356-103433025 (-)
WSB/EiJ MGP_WSBEiJ_G0029008
 protein coding gene Chr5:106326163-106336590 (-)



Homology
more
  • Human Ortholog
    GBP6, guanylate binding protein family member 6
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP6, guanylate binding protein family member 6
  • Links
    NCBI Gene ID: 163351
    neXtProt AC: NX_Q6ZN66
    UniProt: Q6ZN66

  • Chr Location
    1p22.2; chr1:89364059-89388160 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    31
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 76074 NCBI Gene Model | MGI Sequence Detail 41097 C57BL/6J ±  kb
transcript NM_029509 RefSeq | MGI Sequence Detail 2459 C57BL/6  
polypeptide NP_083785 RefSeq | MGI Sequence Detail 525 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein/Atlastin, C-terminal
    IPR037684 Guanylate-binding protein, C-terminal
    IPR036543 Guanylate-binding protein, C-terminal domain superfamily
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:324833 Simpson DS, et al., Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022 Mar 8;55(3):423-441.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory