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Kdm3b Gene Detail
Summary
  • Symbol
    Kdm3b
  • Name
    KDM3B lysine (K)-specific demethylase 3B
  • Synonyms
    5830462I21Rik, JHDM2B, Jmjd1b, mKIAA1082
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923356
    NCBI Gene: 277250
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34910100-34971713 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.73 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923356
 protein coding gene Chr18:34910061-34972423 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024251
 protein coding gene Chr18:33011495-33076104 (+)
A/J MGP_AJ_G0024217
 protein coding gene Chr18:31891937-31955943 (+)
AKR/J MGP_AKRJ_G0024185
 protein coding gene Chr18:32811815-32875192 (+)
BALB/cJ MGP_BALBcJ_G0024217
 protein coding gene Chr18:31951444-32014559 (+)
C3H/HeJ MGP_C3HHeJ_G0023984
 protein coding gene Chr18:32823889-32888282 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024659
 protein coding gene Chr18:34281562-34347199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022099
 protein coding gene Chr18:32034402-32095670 (+)
CAST/EiJ MGP_CASTEiJ_G0023459
 protein coding gene Chr18:32776937-32852331 (+)
CBA/J MGP_CBAJ_G0023952
 protein coding gene Chr18:35209756-35276397 (+)
DBA/2J MGP_DBA2J_G0024084
 protein coding gene Chr18:31548606-31611047 (+)
FVB/NJ MGP_FVBNJ_G0024051
 protein coding gene Chr18:31232960-31296514 (+)
LP/J MGP_LPJ_G0024166
 protein coding gene Chr18:33092778-33159522 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024079
 protein coding gene Chr18:36472477-36539425 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024707
 protein coding gene Chr18:32627546-32692418 (+)
PWK/PhJ MGP_PWKPhJ_G0023203
 protein coding gene Chr18:31751249-31817057 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023011
 protein coding gene Chr18:32904881-32974371 (+)
WSB/EiJ MGP_WSBEiJ_G0023522
 protein coding gene Chr18:32560065-32625345 (+)



Homology
more
  • Human Ortholog
    KDM3B, lysine demethylase 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM3B, lysine demethylase 3B
  • Synonyms
    5qNCA, C5orf7, DIJOS, JMJD1B, NET22
  • Links
    NCBI Gene ID: 51780
    neXtProt AC: NX_Q7LBC6
    UniProt: Q7LBC6

  • Chr Location
    5q31.2; chr5:138352685-138437028 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show partial postnatal lethality, stunted postnatal growth, reduced serum IGF-1 and estradiol levels, prolonged estrous cycles, decreased ovulation rate and fertilization frequency, abnormal decidualization and embryo implantation, and female infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    18
  • cDNA Data
    19
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038773 Ensembl Gene Model | MGI Sequence Detail 61614 C57BL/6J ±  kb
    transcript ENSMUST00000043775 Ensembl | MGI Sequence Detail 6363 Not Applicable  
    polypeptide ENSMUSP00000037628 Ensembl | MGI Sequence Detail 1762 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory