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Sp110 Gene Detail
Summary
  • Symbol
    Sp110
  • Name
    Sp110 nuclear body protein
  • Synonyms
    5031415C07Rik, 52kDa, 5830484A20Rik, Ifi75, Ipr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923364
    NCBI Gene: 109032
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:85504620-85526538 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923364
 protein coding gene Chr1:85498462-85538571 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0016623
 protein coding gene Chr1:89358944-89666247 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014343
 protein coding gene Chr1:78057517-78060847 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0015974
 protein coding gene Chr1:92903846-92905264 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0016147
 protein coding gene Chr1:87281464-87288313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016097
 protein coding gene Chr1:95685821-95686966 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0015370
 protein coding gene Chr1:81915330-81917183 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0015646
 protein coding gene Chr1:85300228-85462458 (+)



Homology
more
  • Human Ortholog
    SP110, SP110 nuclear body protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SP110, SP110 nuclear body protein
  • Synonyms
    IFI41, IFI75, IPR1, VODI
  • Links
    NCBI Gene ID: 3431
    neXtProt AC: NX_Q9HB58
    UniProt: Q9HB58

  • Chr Location
    2q37.1; chr2:230165186-230225729 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SP110 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Mice homozygous for a null allele exhibit normal susceptibility to M. tuberculosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    18
  • cDNA Data
    14
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070034 Ensembl Gene Model | MGI Sequence Detail 21919 C57BL/6J ±  kb
transcript ENSMUST00000093508 Ensembl | MGI Sequence Detail 1921 Not Applicable  
polypeptide ENSMUSP00000091226 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • PDB
    1UFN
  • InterPro Domains
    IPR004865 HSR domain
    IPR043563 Nuclear body protein Sp110/Sp140/Sp140L-like
    IPR000770 SAND domain
    IPR010919 SAND-like domain superfamily
  • GlyGen
    Q8BVK9 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 14
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1890488, MGI:1926064
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:330032 Shi F, et al., Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice. FASEB J. 2022 Aug;36(8):e22445
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory