Klhl15 MGI Mouse Gene Detail - MGI:1923400

Symbol

Klhl15
Name

kelch-like 15
Synonyms

6330500C13Rik

Feature Type

protein coding gene
IDs

MGI:1923400
NCBI Gene: 236904
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:93278205-93321330 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 41.53 cM
Mapping Data

1 experiment

SNPs within 2kb

663 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923400	protein coding gene	ChrX:93275884-93321330 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035909	protein coding gene	ChrX:90632513-90675988 (+)
A/J	MGP_AJ_G0035895	protein coding gene	ChrX:90737509-90781027 (+)
AKR/J	MGP_AKRJ_G0035812	protein coding gene	ChrX:93132221-93176259 (+)
BALB/cJ	MGP_BALBcJ_G0035879	protein coding gene	ChrX:89432681-89475455 (+)
C3H/HeJ	MGP_C3HHeJ_G0035588	protein coding gene	ChrX:91000104-91043588 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036408	protein coding gene	ChrX:93405457-93452538 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033235	protein coding gene	ChrX:88900831-88943924 (+)
CAST/EiJ	MGP_CASTEiJ_G0034873	protein coding gene	ChrX:75680536-75719224 (+)
CBA/J	MGP_CBAJ_G0035562	protein coding gene	ChrX:96099290-96144361 (+)
DBA/2J	MGP_DBA2J_G0035718	protein coding gene	ChrX:89959423-90003810 (+)
FVB/NJ	MGP_FVBNJ_G0035657	protein coding gene	ChrX:89366812-89410449 (+)
LP/J	MGP_LPJ_G0035807	protein coding gene	ChrX:91437613-91488107 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035691	protein coding gene	ChrX:100392100-100453416 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036435	protein coding gene	ChrX:90348607-90392558 (+)
PWK/PhJ	MGP_PWKPhJ_G0034572	protein coding gene	ChrX:73450822-73487852 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034402	protein coding gene	ChrX:76513378-76556565 (+)
WSB/EiJ	MGP_WSBEiJ_G0035014	protein coding gene	ChrX:89147987-89191792 (+)

Human Ortholog

KLHL15, kelch like family member 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL15, kelch like family member 15
Synonyms

HEL-S-305, XLID103
Links

HGNC:29347

NCBI Gene ID: 80311

neXtProt AC: NX_Q96M94

UniProt: Q96M94
Chr Location

Xp22.11; chrX:23983716-24027186 (-) GRCh38

MGI Vertebrate Homology

Klhl15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL15
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl15

Diseases

1 with human KLHL15 associations

				Human Disease	Mouse Models
				non-syndromic X-linked intellectual disability 103 IDs non-syndromic X-linked intellectual disability 103 DOID:0112020 OMIM:300982

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

6 strains or lines available

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl15

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All Sequences

75
RefSeq

26
UniProt

2
CCDS

CCDS30278.1, CCDS30279.1, CCDS41062.1

Ensembl

ENSMUSG00000043929 (Evidence)
NCBI Gene

236904

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043929	Ensembl Gene Model \| MGI Sequence Detail	43126	C57BL/6J	± kb
transcript	ENSMUST00000113915	Ensembl \| MGI Sequence Detail	6241	Not Applicable
polypeptide	ENSMUSP00000109548	Ensembl \| MGI Sequence Detail	604	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009378 kelch-like protein 15

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR047030 Kelch-like protein 15, BACK domain

IPR030597 Kelch-like protein 15, BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 28

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Klhl15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161485	ChrX:93278200-93278210 (+)	0 bp
Tssr161486	ChrX:93278527-93278578 (+)	348 bp
Tssr161487	ChrX:93278588-93278603 (+)	391 bp
Tssr161488	ChrX:93318381-93318392 (+)	40,182 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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