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Zdhhc2 Gene Detail
Summary
  • Symbol
    Zdhhc2
  • Name
    zinc finger, DHHC domain containing 2
  • Synonyms
    5730415P04Rik, 6430583A19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923452
    NCBI Gene: 70546
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:40876526-40946178 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2009 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923452
 protein coding gene Chr8:40876526-40963309 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033552
 protein coding gene Chr8:39228849-39312789 (+)
A/J MGP_AJ_G0033532
 protein coding gene Chr8:37733115-37814957 (+)
AKR/J MGP_AKRJ_G0033456
 protein coding gene Chr8:38850359-38932706 (+)
BALB/cJ MGP_BALBcJ_G0033528
 protein coding gene Chr8:37822656-37904310 (+)
C3H/HeJ MGP_C3HHeJ_G0033240
 protein coding gene Chr8:39241445-39325976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034044
 protein coding gene Chr8:40736997-40838859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030993
 protein coding gene Chr8:34357655-34459949 (+)
CAST/EiJ MGP_CASTEiJ_G0032568
 protein coding gene Chr8:38766593-38854065 (+)
CBA/J MGP_CBAJ_G0033218
 protein coding gene Chr8:42411995-42498433 (+)
DBA/2J MGP_DBA2J_G0033371
 protein coding gene Chr8:37585353-37667132 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0033461
 protein coding gene Chr8:39250497-39334553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033358
 protein coding gene Chr8:42196495-42284426 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034063
 protein coding gene Chr8:39046572-39134850 (+)
PWK/PhJ MGP_PWKPhJ_G0032277
 protein coding gene Chr8:37125831-37212435 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032109
 protein coding gene Chr8:38243893-38335938 (+)
WSB/EiJ MGP_WSBEiJ_G0032683
 protein coding gene Chr8:39244613-39330732 (+)



Homology
more
  • Human Ortholog
    ZDHHC2, zinc finger DHHC-type palmitoyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC2, zinc finger DHHC-type palmitoyltransferase 2
  • Synonyms
    DHHC2, ZNF372
  • Links
    NCBI Gene ID: 51201
    neXtProt AC: NX_Q9UIJ5
    UniProt: Q9UIJ5

  • Chr Location
    8p22; chr8:17156482-17224799 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased susceptibility to imiquimod-induced psoriasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1033
  • Tissues
    139
  • cDNA Data
    32
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70546 NCBI Gene Model | MGI Sequence Detail 69653 C57BL/6J ±  kb
    transcript NM_178395 RefSeq | MGI Sequence Detail 3398 C57BL/6  
    polypeptide P59267 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 33
      Primer pair 2
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917796
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:30814 Neophytou PI, et al., A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Diabetes. 1996 Feb;45(2):127-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory