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Slc38a3 Gene Detail
Summary
  • Symbol
    Slc38a3
  • Name
    solute carrier family 38, member 3
  • Synonyms
    0610012J02Rik, D9Ucla2, Snat3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923507
    NCBI Gene: 76257
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107528353-107546167 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.69 cM, cytoband F1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923507
 protein coding gene Chr9:107527833-107546729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035266
 protein coding gene Chr9:109539805-109561791 (-)
A/J MGP_AJ_G0035245
 protein coding gene Chr9:105548686-105568967 (-)
AKR/J MGP_AKRJ_G0035177
 protein coding gene Chr9:108182582-108201352 (-)
BALB/cJ MGP_BALBcJ_G0035239
 protein coding gene Chr9:105217277-105236826 (-)
C3H/HeJ MGP_C3HHeJ_G0034949
 protein coding gene Chr9:108581807-108600634 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035759
 protein coding gene Chr9:112522116-112541134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032657
 protein coding gene Chr9:102977938-102996727 (-)
CAST/EiJ MGP_CASTEiJ_G0034260
 protein coding gene Chr9:108516736-108535038 (-)
CBA/J MGP_CBAJ_G0034917
 protein coding gene Chr9:116492220-116512274 (-)
DBA/2J MGP_DBA2J_G0035078
 protein coding gene Chr9:105001005-105019988 (-)
FVB/NJ MGP_FVBNJ_G0035026
 protein coding gene Chr9:103770362-103790326 (-)
LP/J MGP_LPJ_G0035154
 protein coding gene Chr9:109736339-109756314 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035065
 protein coding gene Chr9:118106760-118128097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035780
 protein coding gene Chr9:108456823-108475463 (-)
PWK/PhJ MGP_PWKPhJ_G0033967
 protein coding gene Chr9:105322455-105341449 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033802
 protein coding gene Chr9:108508980-108527614 (-)
WSB/EiJ MGP_WSBEiJ_G0034381
 protein coding gene Chr9:108336137-108357270 (-)



Homology
more
  • Human Ortholog
    SLC38A3, solute carrier family 38 member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC38A3, solute carrier family 38 member 3
  • Synonyms
    DEE102, G17, NAT1, SN1, SNAT3
  • Links
    NCBI Gene ID: 10991
    neXtProt AC: NX_Q99624
    UniProt: Q99624

  • Chr Location
    3p21.31; chr3:50205246-50221486 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC38A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU allele exhibit complete postnatal lethality between P18 and P20, altered amino acid levels in the serum, liver and brain, and decreased ammonia excretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    34
  • cDNA Data
    146
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76257 NCBI Gene Model | MGI Sequence Detail 17815 C57BL/6J ±  kb
    transcript NM_023805 RefSeq | MGI Sequence Detail 2622 Not Specified  
    polypeptide Q9DCP2 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000015120 sodium-coupled neutral amino acid transporter 3
      (term hierarchy)
    • InterPro Domains
      IPR013057 Amino acid transporter, transmembrane domain
    • GlyGen
      Q9DCP2 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 148
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8787, MGI:94853
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 15
      Phenotypes 6
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory