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Erp44 Gene Detail
Summary
  • Symbol
    Erp44
  • Name
    endoplasmic reticulum protein 44
  • Synonyms
    1110001E24Rik, Txndc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923549
    NCBI Gene: 76299
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:48193323-48279558 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1656 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923549
 protein coding gene Chr4:48190711-48279635 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028272
 protein coding gene Chr4:46611626-46699219 (-)
A/J MGP_AJ_G0028231
 protein coding gene Chr4:44868447-44956057 (-)
AKR/J MGP_AKRJ_G0028181
 protein coding gene Chr4:46008912-46099071 (-)
BALB/cJ MGP_BALBcJ_G0028251
 protein coding gene Chr4:44984805-45072166 (-)
C3H/HeJ MGP_C3HHeJ_G0027972
 protein coding gene Chr4:46584943-46670119 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028692
 protein coding gene Chr4:48294701-48387772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026001
 protein coding gene Chr4:42222647-42306940 (-)
CAST/EiJ MGP_CASTEiJ_G0027411
 protein coding gene Chr4:46170501-46263505 (-)
CBA/J MGP_CBAJ_G0027938
 protein coding gene Chr4:49852417-49943512 (-)
DBA/2J MGP_DBA2J_G0028088
 protein coding gene Chr4:44754062-44837504 (-)
FVB/NJ MGP_FVBNJ_G0028055
 protein coding gene Chr4:44021763-44108479 (-)
LP/J MGP_LPJ_G0028187
 protein coding gene Chr4:46662654-46750251 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028079
 protein coding gene Chr4:52853542-52963852 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028727
 protein coding gene Chr4:46201391-46290970 (-)
PWK/PhJ MGP_PWKPhJ_G0027136
 protein coding gene Chr4:44873906-44960248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026964
 protein coding gene Chr4:45717559-45805870 (-)
WSB/EiJ MGP_WSBEiJ_G0027489
 protein coding gene Chr4:46139440-46227185 (-)



Homology
more
  • Human Ortholog
    ERP44, endoplasmic reticulum protein 44
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERP44, endoplasmic reticulum protein 44
  • Synonyms
    PDIA10, TXNDC4
  • Links
    NCBI Gene ID: 23071
    neXtProt AC: NX_Q9BS26
    UniProt: Q9BS26

  • Chr Location
    9q31.1; chr9:99979185-100099052 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit light coat colour, small stature and scaly tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    32
  • cDNA Data
    150
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028343 Ensembl Gene Model | MGI Sequence Detail 86236 C57BL/6J ±  kb
    transcript ENSMUST00000030028 Ensembl | MGI Sequence Detail 2624 Not Applicable  
    polypeptide ENSMUSP00000030028 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016862 endoplasmic reticulum resident protein 44
      (term hierarchy)
    • InterPro Domains
      IPR052643 Endoplasmic reticulum resident protein 44
      IPR041870 Endoplasmic reticulum resident protein 44, TRX-like domain b
      IPR041862 Endoplasmic reticulum resident protein 44, TRX-like domain b'
      IPR013766 Thioredoxin domain
      IPR036249 Thioredoxin-like superfamily
    • GlyGen
      Q9D1Q6 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 150

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140383, MGI:2140418
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory