Slc18b1 MGI Mouse Gene Detail - MGI:1923556 - solute carrier family 18, subfamily B, member 1

Symbol

Slc18b1
Name

solute carrier family 18, subfamily B, member 1
Synonyms

1110021L09Rik

Feature Type

protein coding gene
IDs

MGI:1923556
NCBI Gene: 76306
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:23672884-23703866 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 11.12 cM
Mapping Data

1 experiment

SNPs within 2kb

1019 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923556	protein coding gene	Chr10:23672876-23703867 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017073	protein coding gene	Chr10:21719610-21751625 (+)
A/J	MGP_AJ_G0017051	protein coding gene	Chr10:21101986-21134237 (+)
AKR/J	MGP_AKRJ_G0017013	protein coding gene	Chr10:21445674-21480030 (+)
BALB/cJ	MGP_BALBcJ_G0017013	protein coding gene	Chr10:21178793-21208305 (+)
C3H/HeJ	MGP_C3HHeJ_G0016833	protein coding gene	Chr10:21643605-21677829 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017471	protein coding gene	Chr10:22362148-22397131 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015172	protein coding gene	Chr10:19827223-19858057 (+)
CAST/EiJ	MGP_CASTEiJ_G0016414	protein coding gene	Chr10:21537951-21572121 (+)
CBA/J	MGP_CBAJ_G0016806	protein coding gene	Chr10:23365955-23397014 (+)
DBA/2J	MGP_DBA2J_G0016912	protein coding gene	Chr10:20831025-20862869 (+)
FVB/NJ	MGP_FVBNJ_G0016908	protein coding gene	Chr10:20557618-20589654 (+)
LP/J	MGP_LPJ_G0016988	protein coding gene	Chr10:21704096-21739738 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016938	protein coding gene	Chr10:23511646-23560598 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017506	protein coding gene	Chr10:21295325-21330471 (+)
PWK/PhJ	MGP_PWKPhJ_G0016199	protein coding gene	Chr10:20576387-20608068 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015981	protein coding gene	Chr10:21108603-21146635 (+)
WSB/EiJ	MGP_WSBEiJ_G0016477	protein coding gene	Chr10:21406940-21442261 (+)

Human Ortholog

SLC18B1, solute carrier family 18 member B1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC18B1, solute carrier family 18 member B1
Synonyms

C6orf192, dJ55C23.6, VPAT
Links

HGNC:21573

NCBI Gene ID: 116843

neXtProt AC: NX_Q6NT16

UniProt: Q6NT16
Chr Location

6q23.2; chr6:132769370-132813339 (-) GRCh38

MGI Vertebrate Homology

Slc18b1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC18B1
Gene Tree

Slc18b1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Targeted

2
Genomic Mutations

1 involving Slc18b1
Incidental Mutations

APF
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for a conditional allele ubiquitously activated exhibit reduced brain polyamine levels, impaired memory and altered response to addictive substances.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

23
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc18b1

ZFIN slc18b1

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All Sequences

66
RefSeq

18
UniProt

5
CCDS

CCDS48521.1

Ensembl

ENSMUSG00000037455 (Evidence)
NCBI Gene

76306

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037455	Ensembl Gene Model \| MGI Sequence Detail	30983	C57BL/6J	± kb
transcript	ENSMUST00000119597	Ensembl \| MGI Sequence Detail	2837	Not Applicable
polypeptide	ENSMUSP00000112634	Ensembl \| MGI Sequence Detail	457	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030969 MFS-type transporter SLC18B1

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR050930 Major Facilitator Superfamily Vesicular Transporter

IPR036259 MFS transporter superfamily

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All nucleic 24

cDNA 23

Other 1

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc18b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92708	Chr10:23672543-23672558 (+)	-333 bp
Tssr92709	Chr10:23672844-23672949 (+)	13 bp
Tssr92710	Chr10:23672950-23672968 (+)	75 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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